Hydrophobins: multifunctional biosurfactants for interface engineering.

Autor: Berger BW; 1Department of Biomedical Engineering, University of Virginia, Thornton Hall, P.O. Box 400259, Charlottesville, VA 22904 USA.; 2Department of Chemical Engineering, University of Virginia, 214 Chem. Eng., 102 Engineers' Way, Charlottesville, VA 22904 USA., Sallada ND; 1Department of Biomedical Engineering, University of Virginia, Thornton Hall, P.O. Box 400259, Charlottesville, VA 22904 USA.
Jazyk: angličtina
Zdroj: Journal of biological engineering [J Biol Eng] 2019 Jan 23; Vol. 13, pp. 10. Date of Electronic Publication: 2019 Jan 23 (Print Publication: 2019).
DOI: 10.1186/s13036-018-0136-1
Abstrakt: Hydrophobins are highly surface-active proteins that have versatile potential as agents for interface engineering. Due to the large and growing number of unique hydrophobin sequences identified, there is growing potential to engineer variants for particular applications using protein engineering and other approaches. Recent applications and advancements in hydrophobin technologies and production strategies are reviewed. The application space of hydrophobins is large and growing, including hydrophobic drug solubilization and delivery, protein purification tags, tools for protein and cell immobilization, antimicrobial coatings, biosensors, biomineralization templates and emulsifying agents. While there is significant promise for their use in a wide range of applications, developing new production strategies is a key need to improve on low recombinant yields to enable their use in broader applications; further optimization of expression systems and yields remains a challenge in order to use designed hydrophobin in commercial applications.
Competing Interests: Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Databáze: MEDLINE
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