Spinal cord injury by clip-compression induces anxiety and depression-like behaviours in female rats: The role of the inflammatory response.

Autor: do Espírito Santo CC; Programa de Pós-graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil; Laboratório de Neurobiologia da Dor e Inflamação, Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil. Electronic address: karolces@hotmail.com., da Silva Fiorin F; Programa de Pós-graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil; Laboratório de Neurobiologia da Dor e Inflamação, Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Ilha J; Departamento de Fisioterapia, Núcleo de Pesquisa em Lesão da Medula Espinal, Universidade do Estado de Santa Catarina, Florianópolis, Brazil., Duarte MMMF; Programa de Pós-graduação em Farmacologia e Centro de Ciências da Saúde da Universidade Luterana do Brasil, Rio Grande do Sul, Brazil., Duarte T; Programa de Pós-graduação em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil., Santos ARS; Programa de Pós-graduação em Neurociências, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil; Laboratório de Neurobiologia da Dor e Inflamação, Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil. Electronic address: adair.santos@ufsc.br.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2019 May; Vol. 78, pp. 91-104. Date of Electronic Publication: 2019 Jan 16.
DOI: 10.1016/j.bbi.2019.01.012
Abstrakt: Traumatic spinal cord injury (SCI) promotes long-term disability that affects mobility and functional independence. The spinal cord inflammatory response after the initial mechanical insult substantially impacts locomotor impairment and development of neuropsychiatric disorders, including anxiety and depression. However, these psychiatric events are scarcely investigated in females. This study investigated the anxiety/depression-like behaviours and inflammatory responses related to the production/release of pro- and anti-inflammatory cytokines in female adult Wistar rats submitted to severe clip-compression SCI. Data showed that SCI impaired the locomotor performance assessment by the BBB scale, but did not alter exploratory activity in open-field test. Animals' locomotor impairment was associated with anxious and depressive-like behaviours characterised by a decreased amount of time in the open arms of the elevated plus-maze test, and the motivational reduction of social interaction and anhedonia assessed by social exploration and sucrose preference tests. By contrast, SCI decreased the immobility time in the forced swimming test. Moreover, SCI caused a significant increase in local and systemic proinflammatory cytokines (TNF-α, INF-γ, IL-1β, and IL-6) and a reduction in the anti-inflammatory cytokine IL-10. Finally, there were significant negative correlations between depression-like behaviour, but not anxiety, and increased plasma concentrations of TNF-α, IL-1β, IL-6, and INF-γ. Additionally, the laminectomy procedure provoked the inflammatory response associated with reduced sucrose intake in Sham animals, although less expressively than in the SCI group. Collectively, these results indicate that SCI by clip-compression in female rats promotes a neuropsychiatric-like profile associated with an imbalance in the production/release of pro- and anti-inflammatory cytokines.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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