Development of Intestinal Scaffolds that Mimic Native Mammalian Intestinal Tissue.

Autor: Ladd MR; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Costello CM; Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York., Gosztyla C; Department of Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland., Werts AD; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Johnson B; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Fulton WB; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Martin LY; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., Redfield EJ; Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York., Crawford B; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland., Panaparambil R; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland., Sodhi CP; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland., March JC; Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York., Hackam DJ; Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
Jazyk: angličtina
Zdroj: Tissue engineering. Part A [Tissue Eng Part A] 2019 Sep; Vol. 25 (17-18), pp. 1225-1241. Date of Electronic Publication: 2019 Sep 03.
DOI: 10.1089/ten.TEA.2018.0239
Abstrakt: Impact Statement: This study is significant because it demonstrates an attempt to design a scaffold specifically for small intestine using a novel fabrication method, resulting in an architecture that resembles intestinal villi. In addition, we use the versatile polymer poly(glycerol sebacate) (PGS) for artificial intestine, which has tunable mechanical and degradation properties that can be harnessed for further fine-tuning of scaffold design. Moreover, the utilization of PGS allows for future development of growth factor and drug delivery from the scaffolds to promote artificial intestine formation.
Databáze: MEDLINE