Interleukin-4 -590C/T gene polymorphism in Egyptian children with acute lower respiratory infection: A multicenter study.

Autor: Emam AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Shehab MMM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Allah MAN; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Elkoumi MA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Abdelaal NM; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Egypt., Mosabah AAA; Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt., Zakaria MT; Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt., Sherif AM; Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt., Soliman MM; Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt., El-Kaffas RMH; Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt., Abouzeid H; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Abdou MA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Abdalmonem N; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Abdelbaset HR; Department of Pediatrics, Faculty of Medicine, Banha University, Egypt., Mohamed SA; Department of Pediatrics, Al Azhar Faculty of Medicine, Cairo, Egypt., Soliman AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Elashkar SSA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Hegab MS; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Khalil AM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Abdel-Aziz A; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Anany HG; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Salah HE; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt., Abdou AM; Department of Clinical Pathology, Al Azhar Faculty of Medicine, Cairo, Egypt., Elshehawy NA; Department of Anesthesia, Al Azhar Faculty of Medicine, Cairo, Egypt., Elbasyouni HAA; Department of Internal Medicine, Faculty of Medicine, Menoufia University, Egypt., Hafez SFM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Egypt., Abo-Alella DA; Department of Microbiology, Faculty of Medicine, Zagazig University, Egypt., Fawzi MM; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt., Morsi SS; Department of Microbiology, Faculty of Medicine, Zagazig University, Egypt.
Jazyk: angličtina
Zdroj: Pediatric pulmonology [Pediatr Pulmonol] 2019 Mar; Vol. 54 (3), pp. 297-302. Date of Electronic Publication: 2019 Jan 06.
DOI: 10.1002/ppul.24235
Abstrakt: Background: Acute lower respiratory infection (ALRI) is the leading cause of child mortality, especially in the developing world. Polymorphisms in the interleukin 4 (IL-4) gene have been linked to a variety of human diseases.
Objectives: To investigate whether the IL-4 -590C/T (rs2243250) polymorphism could be a genetic marker for susceptibility to ALRIs in young Egyptian children.
Methods: This was a multicenter study conducted on 480 children diagnosed with pneumonia or bronchiolitis, and 480 well-matched healthy control children. Using PCR-RFLP analysis, we genotyped a -590C/T (rs2243250) single nucleotide polymorphism of the IL-4 gene promoter, meanwhile the serum IL-4concentration was measured by ELISA.
Results: The frequency of the IL-4 -590 T/T genotype and T allele were overrepresented in patients with ALRIs in comparison to the control group (OR = 2.0; [95% confidence interval [CI]: 1.38-2.96]; for the T/T genotype) and (OR: 1.3; [95%CI: 1.07-1.56]; for the T allele; P < 0.01). The IL-4 -590 T/T genotype was associated with significantly higher mean serum IL-4 concentration (58.7 ± 13.4 pg/mL) compared to the C/T genotype (47.6 ± 11 pg/mL) and the C/C genotype (34.8 ± 9.6 pg/mL); P < 0.01.
Conclusion: The IL-4 -590C/T (rs2243250) polymorphism may contribute to susceptibility to ALRIs in young Egyptian children.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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