| Autor: |
Kochetova OV; Institute of Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Science, 71 October Ave., Ufa, Russia, 450054., Avzaletdinova DS; Federal State Budgetary Educational Institution of Higher Education 'Bashkir State Medical University' of Healthcare Ministry of the Russian Federation, 3 Lenin St., Ufa, Russia, 45008. hyppocrat@mail.ru., Morugova TV; Federal State Budgetary Educational Institution of Higher Education 'Bashkir State Medical University' of Healthcare Ministry of the Russian Federation, 3 Lenin St., Ufa, Russia, 45008., Mustafina OE; Institute of Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Science, 71 October Ave., Ufa, Russia, 450054. |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular biology reports [Mol Biol Rep] 2019 Feb; Vol. 46 (1), pp. 887-896. Date of Electronic Publication: 2018 Dec 10. |
| DOI: |
10.1007/s11033-018-4544-6 |
| Abstrakt: |
Recent studies have shown that chemokines play an important role in the development of chronic inflammation in adipose tissue, obesity pathogenesis, glucose intolerance and type 2 diabetes. It has also been revealed that some SNPs in chemokine genes are associated with obesity, insulin resistance, type 2 diabetes and diabetes complications in different ethnic groups. The aim of this study was to determine the associations between SNPs in chemokine genes and type 2 diabetes in participants of Tatar ethnic group, living in Bashkortostan. Case-control and cross-sectional study were included in our study design. Five SNPs were genotyped in 440 type 2 diabetes (160 men and 280 women), 58.8 ± 9.2 years old (mean ± SD), BMI 29.3 ± 3.9 kg/m 2 (mean ± SD) patients of Tatar ethnicity, and a control group of 500 Tatars (180 men and 320 women), 55.2 ± 11.6 years old (mean ± SD), BMI 25.9 ± 4.3 kg/m 2 (mean ± SD). The SNPs rs6749704 in CCL20 [odds ratio (OR) = 2.77 (95% CI 1.81-4.25), р = 0.0001], rs2107538 in CCL5 [odds ratio (OR) = 1.80 (95% CI 1.46-2.22), p = 0.0001] were significantly associated with type 2 diabetes. Regression analysis revealed that rs1696941 in CCL11 was associated with the onset age and duration of type 2 diabetes as well as with HbA 1c level (p = 0.034, p = 0.036 and p = 0.0054, respectively). The SNPs rs223828 in CCL17 and rs6749704 in CCL20 were correlated with obesity as estimated by BMI (p = 0.0004, p = 0.029, respectively). Rs223828 in CCL17 revealed the association with postprandial glucose level (p = 0.024) and HbA 1c (p = 0.008). These data demonstrate that variants of chemokine genes are associated with type 2 diabetes and obesity of Tatar ethnic group inhabiting Bashkortostan Republic. Novel associations of the polymorphic loci in CCL20 (rs6749704) and CCL5 (rs2107538) genes with type 2 diabetes had been identified as a result of the conducted research. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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