Economic Evaluation of an Internet-Based Preventive Cognitive Therapy With Minimal Therapist Support for Recurrent Depression: Randomized Controlled Trial.

Autor: Klein NS; Department of Psychology, University of Groningen, Groningen, Netherlands.; Top Referent Traumacentrum, GGZ Drenthe, Beilen, Netherlands., Bockting CL; Department of Psychology, University of Groningen, Groningen, Netherlands.; Department of Psychiatry, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands., Wijnen B; Department of Public Mental Health, Trimbos Institute, Utrecht, Netherlands.; Care and Public Health Research Institute School for Public Health and Primary Care, Department of Health Services Research, Maastricht University, Maastricht, Netherlands., Kok GD; Ambulante Forensische Psychiatrie Noord, GGZ Drenthe, Emmen, Netherlands., van Valen E; Department of Geriatrics, University Medical Center Utrecht, Utrecht, Netherlands., Riper H; Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit, Amsterdam, Netherlands.; Amsterdam Public Health, VU University Medical Center, Amsterdam, Netherlands.; GGZ inGeest, Amsterdam, Netherlands., Cuijpers P; Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit, Amsterdam, Netherlands.; Amsterdam Public Health, VU University Medical Center, Amsterdam, Netherlands., Dekker J; Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit, Amsterdam, Netherlands.; Research Department, Arkin Mental Health Institute, Amsterdam, Netherlands., van der Heiden C; Department of Psychology, Erasmus University Rotterdam, Rotterdam, Netherlands.; PsyQ Mental Health Care Center, Rotterdam, Netherlands., Burger H; Department of Psychiatry, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.; Department of General Practice, University Medical Center Groningen, Groningen, Netherlands., Smit F; Department of Public Mental Health, Trimbos Institute, Utrecht, Netherlands.; Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit, Amsterdam, Netherlands.; Amsterdam Public Health, VU University Medical Center, Amsterdam, Netherlands.
Jazyk: angličtina
Zdroj: Journal of medical Internet research [J Med Internet Res] 2018 Nov 26; Vol. 20 (11), pp. e10437. Date of Electronic Publication: 2018 Nov 26.
DOI: 10.2196/10437
Abstrakt: Background: Major depressive disorder (MDD) is highly recurrent and has a significant disease burden. Although the effectiveness of internet-based interventions has been established for the treatment of acute MDD, little is known about their cost effectiveness, especially in recurrent MDD.
Objectives: Our aim was to evaluate the cost effectiveness and cost utility of an internet-based relapse prevention program (mobile cognitive therapy, M-CT).
Methods: The economic evaluation was performed alongside a single-blind parallel group randomized controlled trial. Participants were recruited via media, general practitioners, and mental health care institutions. In total, 288 remitted individuals with a history of recurrent depression were eligible, of whom 264 were randomly allocated to M-CT with minimal therapist support added to treatment as usual (TAU) or TAU alone. M-CT comprised 8 online lessons, and participants were advised to complete 1 lesson per week. The economic evaluation was performed from a societal perspective with a 24-month time horizon. The health outcomes were number of depression-free days according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, (DSM-IV) criteria assessed with the Structured Clinical Interview for DSM-IV axis I disorders by blinded interviewers after 3, 12, and 24 months. Quality-adjusted life years (QALYs) were self-assessed with the three level version of the EuroQol Five Dimensional Questionnaire (EQ-5D-3L). Costs were assessed with the Trimbos and Institute for Medical Technology Assessment Questionnaire on Costs Associated with Psychiatric Illness (TiC-P). Incremental cost-effectiveness ratios were calculated and cost-effectiveness planes and cost-effectiveness acceptability curves were displayed to assess the probability that M-CT is cost effective compared to TAU.
Results: Mean total costs over 24 months were €8298 (US $9415) for M-CT and €7296 (US $8278) for TAU. No statistically significant differences were found between M-CT and TAU regarding depression-free days and QALYs (P=.37 and P=.92, respectively). The incremental costs were €179 (US $203) per depression-free day and €230,816 (US $261,875) per QALY. The cost-effectiveness acceptability curves suggested that for depression-free days, high investments have to be made to reach an acceptable probability that M-CT is cost effective compared to TAU. Regarding QALYs, considerable investments have to be made but the probability that M-CT is cost effective compared to TAU does not rise above 40%.
Conclusions: The results suggest that adding M-CT to TAU is not effective and cost effective compared to TAU alone. Adherence rates were similar to other studies and therefore do not explain this finding. The participants scarcely booked additional therapist support, resulting in 17.3 minutes of mean total therapist support. More studies are needed to examine the cost effectiveness of internet-based interventions with respect to long-term outcomes and the role and optimal dosage of therapist support. Overall, more research is needed on scalable and cost-effective interventions that can reduce the burden of recurrent MDD.
Trial Registration: Netherlands Trial Register NTR2503; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2503 (Archived by WebCite at http://www.webcitation.org/73aBn41r3).
(©Nicola S Klein, Claudi LH Bockting, Ben Wijnen, Gemma D Kok, Evelien van Valen, Heleen Riper, Pim Cuijpers, Jack Dekker, Colin van der Heiden, Huibert Burger, Filip Smit. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 26.11.2018.)
Databáze: MEDLINE
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