The prevalence of occult hepatitis B infection among the blood donors in a tertiary care hospital, Puducherry.

Autor: Athira KP; Department of Microbiology, JIPMER, Puducherry, India., Vanathy K; Department of Microbiology, JIPMER, Puducherry, India., Kulkarni R; Department of Transfusion Medicine, JIPMER, Puducherry, India., Dhodapkar R; Department of Microbiology, JIPMER, Puducherry, India.
Jazyk: angličtina
Zdroj: Indian journal of medical microbiology [Indian J Med Microbiol] 2018 Jul-Sep; Vol. 36 (3), pp. 426-428.
DOI: 10.4103/ijmm.IJMM_18_32
Abstrakt: Occult hepatitis B infection (OBI) is a cause of concern while screening the blood donors to prevent transfusion-related transmission of infection. This study was conducted to assess the prevalence of OBI using total anti-HBc by ELISA and DNA detection by real time polymerase chain reaction (PCR). The samples included were negative for HBs Ag by ELISA. Out of 1102 samples tested, 156 were positive for total anti-hepatitis B core antigen and 52/156 by real-time PCR. Overall, the prevalence was found to be 4.71% (52/1102). The results indicate that nucleic acid-based testing should be an essential part of screening procedure to prevent missing of OBI.
Competing Interests: There are no conflicts of interest
Databáze: MEDLINE
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