The anemonin content of four different Ranunculus species.

Autor:	Neag T; Vasile Goldiș Western University of Arad, Faculty of Pharmacy, 86 L. Rebreanu St., Arad, Romania., Olah NK; Vasile Goldiș Western University of Arad, Faculty of Pharmacy, 86 L. Rebreanu St., Arad, Romania / SC PlantExtrakt SRL, Radaia, Cluj, Romania., Hanganu D; Iuliu Hațieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 I. Creangă St., Cluj-Napoca, Romania., Benedec D; Iuliu Hațieganu University of Medicine and Pharmacy, Faculty of Pharmacy, 12 I. Creangă St., Cluj-Napoca, Romania., Pripon FF; SC PlantExtrakt SRL, Radaia, Cluj, Romania., Ardelean A; Vasile Goldiș Western University of Arad, Faculty of Pharmacy, 86 L. Rebreanu St., Arad, Romania., Toma CC; Vasile Goldiș Western University of Arad, Faculty of Pharmacy, 86 L. Rebreanu St., Arad, Romania.
Jazyk:	angličtina
Zdroj:	Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2018 Sep; Vol. 31 (5(Supplementary)), pp. 2027-2032.
Abstrakt:	The Ranunculus species are poorly known as medicinal plants. They have potential toxicity given by the ranunculin and its enzymatic degradation compounds: protoanemonin and anemonin. This paper aims to evaluate the anemonin content of four species: R. bulbosus, R. ficaria, R. sardous and R. sceleratus. The evaluation was performed by TLC and HPLC. There were evaluated two types of extracts hydroalcoholic (HA) and glycerol-ethanol (GE). The most concentrated extract in anemonin was found to be the R. sardous aerial part HA extract: 2.66 mg/ml. The lowest anemonin content is in R. sceleratus: 0.13-0.19 mg/ml. In R. bulbosus aerial part the anemonin content is less than the used HPLC method detection limits (7.68 mg/ml). In all cases the GE extracts are less concentrated in anemonin, being more safely for human administration.
Databáze:	MEDLINE
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