Viral load suppression and acquired HIV drug resistance in adults receiving antiretroviral therapy in Viet Nam: results from a nationally representative survey.

Autor:	Dat VQ; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Vietnam., Duong BD; Vietnam Authority of HIV/AIDS Control, Hanoi, Vietnam., Nhan DT; Vietnam Authority of HIV/AIDS Control, Hanoi, Vietnam., Hai NH; Vietnam Authority of HIV/AIDS Control, Hanoi, Vietnam., Anh NTL; National Institute of Hygiene Epidemiology (NIHE), Hanoi, Vietnam., Thu HHK; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Ton T; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Anh LQ; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nghia NT; National Institute of Hygiene Epidemiology (NIHE), Hanoi, Vietnam., Thuong NV; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nghia KV; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Tam TTM; National Institute of Hygiene Epidemiology (NIHE), Hanoi, Vietnam., Hau TP; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Phuc ND; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Thinh VX; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Hien NT; National Institute of Hygiene Epidemiology (NIHE), Hanoi, Vietnam., Lien TTX; Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam., Bertagnolio S; World Health Organization, Geneva, Switzerland., Van NTT; World Health Organization Viet Nam Country Office, Hanoi, Vietnam., Kato M; World Health Organization Viet Nam Country Office, Hanoi, Vietnam.
Jazyk:	angličtina
Zdroj:	Western Pacific surveillance and response journal : WPSAR [Western Pac Surveill Response J] 2018 Aug 20; Vol. 9 (3), pp. 16-24. Date of Electronic Publication: 2018 Aug 20 (Print Publication: 2018).
DOI:	10.5365/wpsar.2018.9.1.008
Abstrakt:	Objective: The purpose of this survey was to estimate the prevalence of viral load (VL) suppression and emergence of HIV drug resistance (HIVDR) among individuals receiving antiretroviral therapy (ART) for 36 months or longer in Viet Nam using a nationally representative sampling method. Methods: The survey was conducted between May and August 2014 using a two-stage cluster design. Sixteen ART clinics were selected using probability proportional to proxy size sampling, and patients receiving ART for at least 36 months were consecutively enrolled. Epidemiological information and blood specimens were collected for HIV-1 VL and HIVDR testing; HIVDR was defined by the Stanford University HIVDR algorithm. Results: Overall, 365 eligible individuals were recruited with a mean age of 38.2 years; 68.4% were men. The mean time on ART was 75.5 months (95% confidence interval [CI]: 69.0-81.9 months), and 93.7% of the patients were receiving non-nucleoside reverse transcriptase inhibitor-based regimens. Of the 365 individuals, 345 (94.7%, 95% CI: 64.1-99.4%) had VL below 1000 copies/mL and 19 (4.6%, 95% CI: 2.8--7.5) had HIVDR mutations. Discussion: Our nationally representative survey found a high level of VL suppression and a low prevalence of HIVDR among individuals who received ART for at least 36 months in Viet Nam. Continued surveillance for HIVDR is important for evaluating and improving HIV programs.
Databáze:	MEDLINE
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