Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior.

Autor:	Yap EL; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA., Greenberg ME; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address: michael_greenberg@hms.harvard.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2018 Oct 24; Vol. 100 (2), pp. 330-348.
DOI:	10.1016/j.neuron.2018.10.013
Abstrakt:	Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As cells function in their respective niches, transcription further allows mature cells to interact dynamically with their external environment while reliably retaining fundamental information about past experiences. In this Review, we provide an overview of the field of activity-dependent transcription in the vertebrate brain and highlight contemporary work that ranges from studies of activity-dependent chromatin modifications to plasticity mechanisms underlying adaptive behaviors. We identify key gaps in knowledge and propose integrated approaches toward a deeper understanding of how activity-dependent transcription promotes the refinement and plasticity of neural circuits for cognitive function. (Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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