A Bifidobacterial pilus-associated protein promotes colonic epithelial proliferation.
Autor: | O'Connell Motherway M; APC Microbiome Ireland, National University of Ireland, Western Road, Cork, Ireland.; School of Microbiology, National University of Ireland, Western Road, Cork, Ireland., Houston A; APC Microbiome Ireland, National University of Ireland, Western Road, Cork, Ireland.; Department of Medicine, National University of Ireland, Cork University Hospital, Cork, Ireland., O'Callaghan G; APC Microbiome Ireland, National University of Ireland, Western Road, Cork, Ireland.; Department of Medicine, National University of Ireland, Cork University Hospital, Cork, Ireland., Reunanen J; Research Programme Unit Immunobiology, Department of Bacteriology and Immunology, Helsinki University, Helsinki, Finland.; Cancer and Translational Medicine Research Unit and Biocenter Oulu, University of Oulu, Oulu, Finland., O'Brien F; APC Microbiome Ireland, National University of Ireland, Western Road, Cork, Ireland., O'Driscoll T; APC Microbiome Ireland, National University of Ireland, Western Road, Cork, Ireland., Casey PG; APC Microbiome Ireland, National University of Ireland, Western Road, Cork, Ireland., de Vos WM; Research Programme Unit Immunobiology, Department of Bacteriology and Immunology, Helsinki University, Helsinki, Finland.; Laboratory of Microbiology, Wageningen University, The Netherlands., van Sinderen D; APC Microbiome Ireland, National University of Ireland, Western Road, Cork, Ireland.; School of Microbiology, National University of Ireland, Western Road, Cork, Ireland., Shanahan F; APC Microbiome Ireland, National University of Ireland, Western Road, Cork, Ireland.; Department of Medicine, National University of Ireland, Cork University Hospital, Cork, Ireland. |
---|---|
Jazyk: | angličtina |
Zdroj: | Molecular microbiology [Mol Microbiol] 2019 Jan; Vol. 111 (1), pp. 287-301. Date of Electronic Publication: 2018 Dec 02. |
DOI: | 10.1111/mmi.14155 |
Abstrakt: | Development of the human gut microbiota commences at birth, with certain bifidobacterial species representing dominant and early colonisers of the newborn gastrointestinal tract. The molecular basis of Bifidobacterium colonisation, persistence and presumed communication with the host has remained obscure. We previously identified tight adherence (Tad) pili from Bifidobacterium breve UCC2003 as an essential colonisation factor. Here, we demonstrate that bifidobacterial Tad pili also promote in vivo colonic epithelial proliferation. A significant increase in cell proliferation was detectable 5 days postadministration of B. breve UCC2003. Using advanced functional genomic approaches, bacterial strains either (a) producing the Tad (© 2018 John Wiley & Sons Ltd.) |
Databáze: | MEDLINE |
Externí odkaz: |