Circadian Rhythms and Mitochondria: Connecting the Dots.
| Autor: | Sardon Puig L; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Valera-Alberni M; Nestlé Institute of Health Sciences, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale Lausanne, Lausanne, Switzerland., Cantó C; Nestlé Institute of Health Sciences, Lausanne, Switzerland.; School of Life Sciences, Ecole Polytechnique Fédérale Lausanne, Lausanne, Switzerland., Pillon NJ; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in genetics [Front Genet] 2018 Oct 08; Vol. 9, pp. 452. Date of Electronic Publication: 2018 Oct 08 (Print Publication: 2018). |
| DOI: | 10.3389/fgene.2018.00452 |
| Abstrakt: | Circadian rhythms provide a selective advantage by anticipating organismal nutrient needs and guaranteeing optimal metabolic capacity during active hours. Impairment of circadian rhythms is associated with increased risk of type 2 diabetes and emerging evidence suggests that metabolic diseases are linked to perturbed clock machinery. The circadian clock regulates many transcriptional-translational processes influencing whole cell metabolism and particularly mitochondrial activity. In this review, we survey the current literature related to cross-talks between mitochondria and the circadian clock and unravel putative molecular links. Understanding the mechanisms that link metabolism and circadian responses to transcriptional modifications will provide valuable insights toward innovative therapeutic strategies to combat the development of metabolic disease. |
| Databáze: | MEDLINE |
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