Sequential specification of oligodendrocyte lineage cells by distinct levels of Hedgehog and Notch signaling.

Autor: Ravanelli AM; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA., Kearns CA; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA., Powers RK; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA., Wang Y; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA., Hines JH; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA., Donaldson MJ; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA., Appel B; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: bruce.appel@ucdenver.edu.
Jazyk: angličtina
Zdroj: Developmental biology [Dev Biol] 2018 Dec 15; Vol. 444 (2), pp. 93-106. Date of Electronic Publication: 2018 Oct 19.
DOI: 10.1016/j.ydbio.2018.10.004
Abstrakt: During development of the central nervous system oligodendrocyte precursor cells (OPCs) give rise to both myelinating oligodendrocytes and NG2 glia, which are the most proliferative cells in the adult mammalian brain. NG2 glia retain characteristics of OPCs, and some NG2 glia produce oligodendrocytes, but many others persist throughout adulthood. Why some OPCs differentiate as oligodendrocytes during development whereas others persist as OPCs and acquire characteristics of NG2 glia is not known. Using zebrafish spinal cord as a model, we found that OPCs that differentiate rapidly as oligodendrocytes and others that remain as OPCs arise in sequential waves from distinct neural progenitors. Additionally, oligodendrocyte and persistent OPC fates are specified during a defined critical period by small differences in Shh signaling and Notch activity, which modulates Shh signaling response. Thus, our data indicate that OPCs fated to produce oligodendrocytes or remain as OPCs during development are specified as distinct cell types, raising the possibility that the myelinating potential of OPCs is set by graded Shh signaling activity.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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