Prevalence and risk factors of Occult Hepatitis C infections in blood donors from Mexico City.

Autor: Martínez-Rodríguez ML; Unidad de Investigación Médica en Inmunología e Infectología, Centro Médico Nacional 'La Raza', Delegación 2 Noreste del D.F., Instituto Mexicano del Seguro Social, Mexico City, Mexico., Uribe-Noguez LA; Unidad de Investigación Médica en Inmunología e Infectología, Centro Médico Nacional 'La Raza', Delegación 2 Noreste del D.F., Instituto Mexicano del Seguro Social, Mexico City, Mexico., Arroyo-Anduiza CI; Banco Central de Sangre, Centro Médico Nacional 'La Raza', Delegación 2 Noreste del D.F., Instituto Mexicano del Seguro Social, Mexico City, Mexico., Mata-Marin JA; Hospital de Infectología, Centro Médico Nacional 'La Raza', Delegación 2 Noreste del D.F., Instituto Mexicano del Seguro Social. Mexico City, Mexico., Benitez-Arvizu G; Banco Central de Sangre, Centro Médico Nacional 'Siglo XXI', Delegación Sur, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Portillo-López ML; Banco Central de Sangre, Centro Médico Nacional 'Siglo XXI', Delegación Sur, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Ocaña-Mondragón A; Unidad de Investigación Médica en Inmunología e Infectología, Centro Médico Nacional 'La Raza', Delegación 2 Noreste del D.F., Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Oct 19; Vol. 13 (10), pp. e0205659. Date of Electronic Publication: 2018 Oct 19 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0205659
Abstrakt: Background: The circulatory system is the main mechanism for transmission of the Hepatitis C Virus (HCV). A new class of HCV infections, Occult HCV infection (OCI), is defined as the presence of HCV-RNA in hepatocytes with the absence of HCV in the serum/plasma utilizing current laboratory assays. Different groups have reported the prevalence of OCI; however, its associated risk factors have not been established. In Mexico, there are no reports about OCI, so the objective of our study was to determine the prevalence of OCI in total blood donors in Mexico City, as well as its associated risk factors.
Methods: Blood donors that were considered eligible for donation, according to NOM 253-SSA1-2012, were randomly selected. Demographic data was collected from 1,037 donors. Plasma and peripheral blood mononuclear cells were assessed for HCV-RNA. The presence of HCV-RNA was determined by nested PCR for the 5'-UTR region. Logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (95%CI) to determine the level of association.
Results: The prevalence of OCI was 3.4% among blood donors. Homosexual relationships (OR = 5.52, 95%CI: 1.53-19.92, p<0.05) and acupuncture (OR = 3.56, 95%CI: 1.41-8.98, p<0.05) were significantly associated with OCI.
Conclusion: There is a significant presence of OCI in the blood donor population in Mexico City. The main risk factors for OCI transmission are homosexual relationships and acupuncture. This study supports the increased use of sensitive and specific screening tests for blood bank testing.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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