Live imaging of the pulmonary immune environment.

Autor: Looney MR; Department of Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA; Department of Laboratory Medicine, University of California, San Francisco (UCSF), San Francisco, CA 94143, USA., Headley MB; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: mheadley@fredhutch.org.
Jazyk: angličtina
Zdroj: Cellular immunology [Cell Immunol] 2020 Apr; Vol. 350, pp. 103862. Date of Electronic Publication: 2018 Oct 09.
DOI: 10.1016/j.cellimm.2018.09.007
Abstrakt: The lung represents a unique immune environment. The primary function of the lung is to enable gas exchange by facilitating the transfer of oxygen into and carbon dioxide out of the blood. However, as a direct byproduct of this process the lung is also constantly exposed to particles, allergens, and pathogens alongside air itself. Due to this, the pulmonary immune system exists in a fine balance between quiescence and inflammation, deviations from which can lead to a failure in respiratory function. A rich history exists attempting to define the critical features of lung immunity, and most recently advances in intravital microscopy have enabled the visualization of intercellular immune dynamics in both steady-state and a variety of disease conditions. In this review, we will summarize a variety of approaches to intravital lung imaging as well as how its application has advanced our understanding of normal lung function as well as disease states such as pulmonary metastasis, asthma, and lung injury.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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