Plasma markers of myocardial inflammation at isolated atrial fibrillation.

Autor: Sazonova SI; Cardiology Research Institute Tomsk National Research Medical Center Russian Academy of Science Tomsk Russia., Ilushenkova JN; Cardiology Research Institute Tomsk National Research Medical Center Russian Academy of Science Tomsk Russia., Batalov RE; Cardiology Research Institute Tomsk National Research Medical Center Russian Academy of Science Tomsk Russia., Gusakova AM; Cardiology Research Institute Tomsk National Research Medical Center Russian Academy of Science Tomsk Russia., Saranchina JV; Medical-psychological-social Institute Katanov Khakass State University Abakan Russia., Rogovskaya JV; Cardiology Research Institute Tomsk National Research Medical Center Russian Academy of Science Tomsk Russia., Popov SV; Cardiology Research Institute Tomsk National Research Medical Center Russian Academy of Science Tomsk Russia.
Jazyk: angličtina
Zdroj: Journal of arrhythmia [J Arrhythm] 2018 Jun 26; Vol. 34 (5), pp. 493-500. Date of Electronic Publication: 2018 Jun 26 (Print Publication: 2018).
DOI: 10.1002/joa3.12083
Abstrakt: Background: Atrial fibrillation (AF) is one of the widest spread forms of arrhythmia, which is associated with the increased mortality and thromboembolic complications. To date, the involvement of renin-angiotensin-aldosterone system and immunomediators of inflammation into the mechanisms of development and maintenance of isolated AF is not clear. Specificity of their changes with respect to the latent myocarditis at AF is not proved.
Methods: In 96 patients with persistent isolated atrial fibrillation (IsAF), scheduled for radiofrequency ablation and endomyocardial biopsy (EMB), and in 20 healthy volunteers (HVT), levels of plasma tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-10, fatty acid-binding protein (FABP), neopterin, C-reactive protein (CRP) were determined by ELISA, level of aldosterone and the renin activity were determined by radioimmunoassay. Results were compared between the study and HVT groups and related to the EMB data.
Results: Endomyocardial biopsy revealed lymphocytic myocarditis in 29%, immunohistochemical signs of viruses' persistence in the myocardium-in 43.8% of patient. We formed 4 subgroups: «myocarditis», «fibrosis», «virus positive», «virus negative». In the group «myocarditis», level of IL-6 was significantly higher than in group «fibrosis» ( P  < .01). ROC analysis showed its sensitivity 75%, specificity 75% (AUC = 0.759, Cutoff Value > 1.6 pg/mL, P  < .01). In the group «virus positive», level of neopterin was significantly higher than in group «virus negative» ( P  < .01), with sensitivity 51%, specificity 84% (AUC = 0.675, Cutoff Value > 13.2 nmol/L, P  < .01).
Conclusion: Levels of plasma IL-6 and neopterin may serve as a marker of latent viral myocarditis in IsAF.
Databáze: MEDLINE
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