Multifunctional System Polyaniline-Decorated ZIF-8 Nanoparticles as a New Chemo-Photothermal Platform for Cancer Therapy.

Autor:	Silva JSF; Fundamental Department of Chemistry and Materials Science Program, Federal University of Pernambuco, 50670-901 Recife, Pernambuco, Brazil., Silva JYR; Fundamental Department of Chemistry and Materials Science Program, Federal University of Pernambuco, 50670-901 Recife, Pernambuco, Brazil., de Sá GF; Fundamental Department of Chemistry and Materials Science Program, Federal University of Pernambuco, 50670-901 Recife, Pernambuco, Brazil., Araújo SS; Department of Sciences Biological, Federal Rural University of Pernambuco, 52171-900 Recife, Pernambuco, Brazil., Filho MAG; Department of Sciences Biological, Federal Rural University of Pernambuco, 52171-900 Recife, Pernambuco, Brazil., Ronconi CM; Department of Inorganic Chemistry, Fluminense Federal University Valonguinho, 24.020-150 Niterói, Rio de Janeiro, Brazil., Santos TC; Department of Inorganic Chemistry, Fluminense Federal University Valonguinho, 24.020-150 Niterói, Rio de Janeiro, Brazil., Júnior SA; Fundamental Department of Chemistry and Materials Science Program, Federal University of Pernambuco, 50670-901 Recife, Pernambuco, Brazil.; Fundamental Department of Chemistry and Materials Science Program, Federal University of Pernambuco, 50670-901 Recife, Pernambuco, Brazil.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2018 Sep 30; Vol. 3 (9), pp. 12147-12157. Date of Electronic Publication: 2018 Sep 27.
DOI:	10.1021/acsomega.8b01067
Abstrakt:	Polyaniline-decorated ZIF-8 nanoparticles (nPANI@nZIF-8) were easily synthesized and employed as a multifunctional system for the delivery of the antitumor drug 5-fluorouracil (5-FU). Because of the storage ability of the network ZIF-8, 68% of the total amount of the 5-FU drug was released at pH 5.2. The system exhibits absorption in the near-infrared (NIR) region and can be used in the photothermal therapy owing to the presence of nPANI, which has a strong NIR uptake. This absorption causes local hyperthermia by aiding in the diffusion of the drug molecules contained by the polymer into nPANI@nZIF-8/5-FU achieving a greater release of the 5-FU drug, about 80% activated by an NIR laser (λ = 980 nm). This hyperthermia reached about 70 °C (200 μL, 1 mg mL -1 nPANI@nZIF-8), which was directly proportional to the concentration of the material. Therefore, our work can aid in the construction of new chemo-photothermal platforms that may be employed in cancer therapy. Competing Interests: The authors declare no competing financial interest.
Databáze:	MEDLINE
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