Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment.

Autor: Sheu SJ; Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, sjiuansheu@gmail.com.; Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, sjiuansheu@gmail.com., Lee YY; Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, sjiuansheu@gmail.com., Horng YH; Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, sjiuansheu@gmail.com., Lin HS; Department of Health-Business Administration, Fooyin University, Kaohsiung, Taiwan., Lai WY; Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, sjiuansheu@gmail.com., Tsen CL; Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, sjiuansheu@gmail.com.
Jazyk: angličtina
Zdroj: Clinical ophthalmology (Auckland, N.Z.) [Clin Ophthalmol] 2018 Sep 26; Vol. 12, pp. 1887-1893. Date of Electronic Publication: 2018 Sep 26 (Print Publication: 2018).
DOI: 10.2147/OPTH.S173956
Abstrakt: Purpose: To investigate optical coherence tomography (OCT) characteristics in diabetic macular edema (DME) over time and after treatment.
Patients and Methods: OCT morphological features in DME eyes treated with ranibizumab with at least 1 year of follow-up were retrospectively analyzed.
Results: Thirty-five eyes were included. From baseline to Month 12, mean visual gain was 7.2±13.6 letters and mean central retinal thickness reduction was 61.9±121.8 μm. Fovea-involving ellipsoid zone (EZ) disruption was significantly associated with final vision of <70 letters. Subretinal fluid at baseline was present only in eyes naïve to previous intravitreal pharmacotherapy and was related to better visual gain and fewer injections. Treatment-naïve eyes had shorter DME duration and less EZ damage.
Conclusion: DME characteristics on OCT may change over time or after treatment. Subretinal fluid may be associated with earlier change and less EZ damage in DME.
Competing Interests: Disclosure The authors report no conflicts of interest in this work.
Databáze: MEDLINE
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