Safety and immunogenicity of plant-produced African horse sickness virus-like particles in horses.

Autor: Dennis SJ; Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, 7701, South Africa., O'Kennedy MM; Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, 0001, South Africa., Rutkowska D; Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, 0001, South Africa., Tsekoa T; Council for Scientific and Industrial Research (CSIR) Biosciences, Pretoria, 0001, South Africa., Lourens CW; Department of Veterinary Tropical Diseases, Faculty of Veterinary Sciences, University of Pretoria, Onderstepoort, Pretoria, 0110, South Africa., Hitzeroth II; Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, 7701, South Africa., Meyers AE; Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, 7701, South Africa. ann.meyers@uct.ac.za., Rybicki EP; Biopharming Research Unit, Department of Molecular and Cell Biology, University of Cape Town, Rondebosch, Cape Town, 7701, South Africa.; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa.
Jazyk: angličtina
Zdroj: Veterinary research [Vet Res] 2018 Oct 11; Vol. 49 (1), pp. 105. Date of Electronic Publication: 2018 Oct 11.
DOI: 10.1186/s13567-018-0600-4
Abstrakt: African horse sickness (AHS) is caused by multiple serotypes of the dsRNA AHSV and is a major scourge of domestic equids in Africa. While there are well established commercial live attenuated vaccines produced in South Africa, risks associated with these have encouraged attempts to develop new and safer recombinant vaccines. Previously, we reported on the immunogenicity of a plant-produced AHS serotype 5 virus-like particle (VLP) vaccine, which stimulated high titres of AHS serotype 5-specific neutralizing antibodies in guinea pigs. Here, we report a similar response to the vaccine in horses. This is the first report demonstrating the safety and immunogenicity of plant-produced AHS VLPs in horses.
Databáze: MEDLINE
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