Melioidosis in Bangladesh: A Clinical and Epidemiological Analysis of Culture-Confirmed Cases.

Autor:	Chowdhury FR; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. mastershakil@hotmail.com.; Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, Thailand. mastershakil@hotmail.com.; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, UK. mastershakil@hotmail.com.; Department of Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh. mastershakil@hotmail.com., Jilani MSA; Department of Microbiology, Ibrahim Medical College, Dhaka 1000, Bangladesh. jilanimsa@gmail.com., Barai L; Department of Microbiology, BIRDEM General Hospital, Dhaka 1000, Bangladesh. barai_lovely@yahoo.com., Rahman T; Department of Microbiology, BIRDEM General Hospital, Dhaka 1000, Bangladesh. tanjila_lo@yahoo.com., Saha MR; Department of Microbiology, BIRDEM General Hospital, Dhaka 1000, Bangladesh. milisaha77@yahoo.com., Amin MR; Department of Medicine, Dhaka Medical College, Dhaka 1000, Bangladesh. robedamin@yahoo.com., Fatema K; Department of Critical Care Medicine, BIRDEM General Hospital, Dhaka 1000, Bangladesh. drkanizfatemasb@gmail.com., Islam KMS; Department of Microbiology, BIRDEM General Hospital, Dhaka 1000, Bangladesh. kmshahid2000@yahoo.com., Faiz MA; Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, Thailand. drmafaiz@gmail.com.; Dev Care Foundation, Dhaka 1205, Bangladesh. drmafaiz@gmail.com., Dunachie SJ; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. susie.dunachie@ndm.ox.ac.uk.; Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, Thailand. susie.dunachie@ndm.ox.ac.uk.; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, UK. susie.dunachie@ndm.ox.ac.uk., Dance DAB; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK. david.d@tropmedres.ac.; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Vientiane 0100, Laos. david.d@tropmedres.ac.; Faculty of Tropical Medicine and Infectious Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. david.d@tropmedres.ac.
Jazyk:	angličtina
Zdroj:	Tropical medicine and infectious disease [Trop Med Infect Dis] 2018 Apr 09; Vol. 3 (2). Date of Electronic Publication: 2018 Apr 09.
DOI:	10.3390/tropicalmed3020040
Abstrakt:	Melioidosis is known to occur in Bangladesh, but there are few reports about the condition in the published international literature. We set out to review all known cases of melioidosis in the country to date, using both retrospective and prospective data. A web-based literature search was conducted to identify all published case reports, original articles and conference abstracts. Cases were also included from a prospective study conducted in 2017. Fifty-one cases were identified between 1961 and 2017. Cases have been reported from sixteen out of the 64 districts of Bangladesh. The median age of the patients at presentation was 45 years (IQR 37⁻52), with a significant male (77%) predominance. Many patients (14/39; 36%) were farmers and 83% had diabetes mellitus. A skin/soft tissue abscess was the most common primary clinical presentation (13/49; 27%), followed by septic arthritis (10/49; 20%), pneumonia, and a deep-seated abscess/organ abscess (7/49; 14%). The major challenges to the diagnosis and treatment of melioidosis in Bangladesh are the lack of resources and the lack of awareness of melioidosis. Capacity development programs are urgently required to define the burden of disease and to tackle the mortality rates. Competing Interests: The authors declare no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
Databáze:	MEDLINE
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