X-ray dark-field imaging of the human lung-A feasibility study on a deceased body.

Autor: Willer K; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany., Fingerle AA; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Gromann LB; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany., De Marco F; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany., Herzen J; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany., Achterhold K; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany., Gleich B; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany., Muenzel D; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Scherer K; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany., Renz M; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Renger B; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Kopp F; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Kriner F; Institute of Forensic Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Fischer F; Institute of Forensic Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Braun C; Institute of Forensic Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Auweter S; Institute of Clinical Radiology, Ludwig-Maximilians-University Munich, Munich, Germany., Hellbach K; Institute of Clinical Radiology, Ludwig-Maximilians-University Munich, Munich, Germany., Reiser MF; Institute of Clinical Radiology, Ludwig-Maximilians-University Munich, Munich, Germany., Schroeter T; Karlsruhe Institute of Technology, Institute of Microstructure Technology, Eggenstein-Leopoldshafen, Germany., Mohr J; Karlsruhe Institute of Technology, Institute of Microstructure Technology, Eggenstein-Leopoldshafen, Germany., Yaroshenko A; Philips Medical Systems DMC GmbH, Hamburg, Germany., Maack HI; Philips Medical Systems DMC GmbH, Hamburg, Germany., Pralow T; Philips Medical Systems DMC GmbH, Hamburg, Germany., van der Heijden H; Philips Medical Systems DMC GmbH, Hamburg, Germany., Proksa R; Philips GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany., Koehler T; Philips GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany.; Institute for Advanced Study, Technical University of Munich, Garching, Germany., Wieberneit N; Philips Medical Systems DMC GmbH, Hamburg, Germany., Rindt K; Philips Medical Systems DMC GmbH, Hamburg, Germany., Rummeny EJ; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Pfeiffer F; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Institute for Advanced Study, Technical University of Munich, Garching, Germany., Noël PB; Department of Physics and Munich School of BioEngineering, Technical University of Munich, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Sep 27; Vol. 13 (9), pp. e0204565. Date of Electronic Publication: 2018 Sep 27 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0204565
Abstrakt: Disorders of the lungs such as chronic obstructive pulmonary disease (COPD) are a major cause of chronic morbidity and mortality and the third leading cause of death in the world. The absence of sensitive diagnostic tests for early disease stages of COPD results in under-diagnosis of this treatable disease in an estimated 60-85% of the patients. In recent years a grating-based approach to X-ray dark-field contrast imaging has shown to be very sensitive for the detection and quantification of pulmonary emphysema in small animal models. However, translation of this technique to imaging systems suitable for humans remains challenging and has not yet been reported. In this manuscript, we present the first X-ray dark-field images of in-situ human lungs in a deceased body, demonstrating the feasibility of X-ray dark-field chest radiography on a human scale. Results were correlated with findings of computed tomography imaging and autopsy. The performance of the experimental radiography setup allows acquisition of multi-contrast chest X-ray images within clinical boundary conditions, including radiation dose. Upcoming clinical studies will have to demonstrate that this technology has the potential to improve early diagnosis of COPD and pulmonary diseases in general.
Competing Interests: A.Y., H-I.M., T.P., H.H., R.P., T.K., N.W., and K.R. are employees of Philips Healthcare. The remaining authors have no competing interests and had complete, unrestricted access to the study data at all stages of the study. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development or marketed products to declare.
Databáze: MEDLINE
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