Attraction of phlebotomine sandflies to volatiles from skin odors of individuals residing in an endemic area of tegumentary leishmaniasis.

Autor: Tavares DDS; Instituto Gonçalo Moniz-Fiocruz-Salvador, Bahia-Brazil.; Faculdade de Medicina da Universidade Federal da Bahia (UFBA)-Salvador, Bahia-Brazil.; Faculdade de Medicina do Centro Universitário Christus (UNICHRISTUS)-Fortaleza, Ceará -Brazil., Salgado VR; Instituto Gonçalo Moniz-Fiocruz-Salvador, Bahia-Brazil., Miranda JC; Instituto Gonçalo Moniz-Fiocruz-Salvador, Bahia-Brazil., Mesquita PRR; Instituto de Química da Universidade Federal da Bahia (UFBA)-Salvador, Bahia-Brazil., Rodrigues FM; Instituto de Química da Universidade Federal da Bahia (UFBA)-Salvador, Bahia-Brazil., Barral-Netto M; Instituto Gonçalo Moniz-Fiocruz-Salvador, Bahia-Brazil.; Faculdade de Medicina da Universidade Federal da Bahia (UFBA)-Salvador, Bahia-Brazil.; Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT)-Salvador, Bahia-Brazil., de Andrade JB; Instituto de Química da Universidade Federal da Bahia (UFBA)-Salvador, Bahia-Brazil.; Instituto Nacional de Ciência e Tecnologia em Energia e Ambiente (INCT-EA)-Salvador, Bahia-Brazil., Barral A; Instituto Gonçalo Moniz-Fiocruz-Salvador, Bahia-Brazil.; Faculdade de Medicina da Universidade Federal da Bahia (UFBA)-Salvador, Bahia-Brazil.; Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia (iii-INCT)-Salvador, Bahia-Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Sep 24; Vol. 13 (9), pp. e0203989. Date of Electronic Publication: 2018 Sep 24 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0203989
Abstrakt: Background: Many studies have investigated what could attract insects of medical importance and a crucial role has lately been attributed to human skin odors. Most of these researches have been concerned with mosquitoes, e.g., vectors of dengue and malaria. Little is known about volatile organic compounds (VOCs) from human skin odors and their effects on leishmania vectors.
Objective: The present study aimed to identify the VOCs from human skin that can be attractive to female anthropophilic phlebotomine sandflies.
Results: Forty-two VOCs were identified from skin odors of 33 male volunteers, seven of which were tested in wind tunnel assays employing field-captured phlebotomine sandflies (75.4% identified as Lutzomyia intermedia). Hexane and (E)-oct-3-en-1-ol (octenol) were used as negative and positive controls, respectively. 2-Phenylacetaldehyde (hereafter called phenylacetaldehyde), 6-methylhept-5-en-2-one (also known as sulcatone), nonadecane and icosane were found to activate female phlebotomine sandflies, but only phenylacetaldehyde, 6-methylhepten-5-en-2-one and icosane elicited attraction responses.
Conclusions: These results suggest that phenylacetaldehyde, 6-methylhepten-5-en-2-one and icosane may be suitable candidates for attractiveness experimentation in the field which can be an important tool to develop strategies concerning human beings protection against phlebotomine sandflies bites and consequently against leishmaniasis.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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