Anaphylaxis triggers in a large tertiary care hospital in Qatar: a retrospective study.

Autor: Abunada T; 1Biomedical Science Department, College of Health Science, Qatar University, P.O. Box 2713, Doha, Qatar., Al-Nesf MA; 2Allergy and Immunology Unit, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar., Thalib L; 3College of Health Science, Qatar University, P.O. Box 2713, Doha, Qatar., Kurdi R; 4Department, College of Health Science, Qatar University, P.O. Box 2713, Doha, Qatar., Khalil S; 5Allergy & Clinical Immunology Unit, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar., ElKassem W; 6Pharmacy Department, Women's Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar., Mobayed HM; 7Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar., Zayed H; 1Biomedical Science Department, College of Health Science, Qatar University, P.O. Box 2713, Doha, Qatar.
Jazyk: angličtina
Zdroj: The World Allergy Organization journal [World Allergy Organ J] 2018 Sep 04; Vol. 11 (1), pp. 20. Date of Electronic Publication: 2018 Sep 04 (Print Publication: 2018).
DOI: 10.1186/s40413-018-0200-9
Abstrakt: Background: Anaphylaxis is a serious allergic disease that may lead to death if not immediately recognized and treated. Triggers of anaphylaxis including food, drugs, and insect stings can vary widely. The incidence of anaphylaxis seems to be affected by age, sex, atopy, and geographic location. This study aims to examine the common triggers of anaphylaxis in Qatar.
Methods: A total of 1068 electronic medical records were audited using power chart system: 446 from the medical coding system of anaphylaxis and 622 from the epinephrine auto-injectors (EAIs) dispensed during January 2012-December 2017.
Results: Of 1068 patients, 574 (53.5%) had anaphylaxis; male to female ratio was 1.2, and 300 patients (77.9%) were less than 10 years old. The common triggers were food ( n  = 316, 55.0%), insect stings ( n  = 161, 28.0%), and drugs ( n  = 103, 17.9%). Common anaphylaxis food triggers were nuts ( n  = 173, 30.1%), eggs ( n  = 89, 15.5%), and seafood ( n  = 72, 12.5%), and common anaphylaxis medication triggers were antibiotics ( n  = 49, 8.5%) and nonsteroidal anti-inflammatory drugs ( n  = 30, 5.2%). Interestingly, 135 anaphylactic patients (23.5%) were due to black ant stings. The anaphylaxis triggers varied significantly between children and adults. Among children (less than 10 years), three quarters of the events were triggered by food (223, 74.3%) while among adults (20-55 years), insect stings ( n  = 59, 43.0%) and drugs ( n  = 44, 32.0%) were dominant.
Discussion: This is the first national study stratifying anaphylaxis triggers among different age groups in Qatar. This study will serve as a guide for clinical practice in allergy clinics in Qatar and will help to assess future trends of anaphylaxis in Qatar.
Competing Interests: Ethical Approval: This retrospective study was ethically approved by the IRB committee of Medical Research Centre- Hamad Medical Corporation (IRB-HMC) (IRB#17122/17) with expedited status. For more information, kindly contact irb@hamad.qa, Tel: 00974–44,390,614.The study was a retrospective study. IRB-HMC approved the study for waiver of consent; provided that the methods used to protect patient confidentiality were judged to be adequate.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Databáze: MEDLINE
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