| Autor: |
Ginanjar E; Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia. ekginanjar@gmail.com., Indrawati L; Department of Clinical Pathology, Faculty of Medicine, University of Indonesia/Dr Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia. lilikindrawati.dr@gmail.com., Setianingsih I; Eijkman Institute for Molecular Biology, Jakarta 10430, Indonesia. ning@eijkman.go.id., Atmakusumah D; Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia. endjum@hotmail.com., Harahap A; Eijkman Institute for Molecular Biology, Jakarta 10430, Indonesia. alida@eijkman.go.id., Timan IS; Department of Clinical Pathology, Faculty of Medicine, University of Indonesia/Dr Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia. ina_sutanto@yahoo.com., Marx JJM; Department of Medical Microbiology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands. jjmmarx@me.com. |
| Abstrakt: |
Plasma non-transferrin-bound iron (NTBI) is potentially harmful due to the generation of free radicals that cause tissue damage in vascular and other diseases. Studies in iron-replete and iron-deficient subjects, receiving a single oral test dose of Fe(II)SO₄ or NaFe(III)EDTA with water, revealed that FeSO₄ was well absorbed when compared with NaFeEDTA, while only the Fe(II) compound showed a remarkable increase of NTBI. As NaFeEDTA is successfully used for food fortification, a double-blind randomized cross-over trial was conducted in 11 healthy women with uncomplicated iron deficiency. All subjects received a placebo, 6.5 mg FeSO₄, 65 mg FeSO₄, 6.5 mg NaFeEDTA, and 65 mg NaFeEDTA with a traditional Indonesian breakfast in one-week intervals. Blood tests were carried out every 60 min for five hours. NTBI detection was performed using the fluorescein-labeled apotransferrin method. Plasma iron values were highly increased after 65 mg NaFeEDTA, twice as high as after FeSO₄. A similar pattern was seen for NTBI. After 6.5 mg of NaFeEDTA and FeSO₄, NTBI was hardly detectable. NaFeEDTA was highly effective for the treatment of iron deficiency if given with a meal, inhibiting the formation of nonabsorbable Fe-complexes, while NTBI did not exceed the range of normal values for iron-replete subjects. |
