Synthesis and Antiviral Activity of Water-Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4-Dichlorophenyl Units.

Autor: Voronov II; Institute for Problems of Chemical Physics of RAS, Semenov Prospect 1, Chernogolovka, 142432, Russia., Martynenko VM; Institute for Problems of Chemical Physics of RAS, Semenov Prospect 1, Chernogolovka, 142432, Russia., Chernyak AV; Institute for Problems of Chemical Physics of RAS, Semenov Prospect 1, Chernogolovka, 142432, Russia., Balzarini J; Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000, Leuven, Belgium., Schols D; Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000, Leuven, Belgium., Troshin PA; Institute for Problems of Chemical Physics of RAS, Semenov Prospect 1, Chernogolovka, 142432, Russia.; Skolkovo Institute of Science and Technology, Nobel St. 3, Moscow, 143026, Russia.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2018 Nov; Vol. 15 (11), pp. e1800293. Date of Electronic Publication: 2018 Oct 29.
DOI: 10.1002/cbdv.201800293
Abstrakt: We have synthesized a series of water-soluble polycarboxylic derivatives of [60]fullerene with a gradually changed polarity by combining three to five polar (ionic) malonate addends with two to zero hydrophobic dichlorobenzene units and explored their antiviral activity. It has been shown that decreasing the number of the ionogenic carboxylic groups in the molecules enhanced their antiviral activity against HIV-1 and suppressed their action against HIV-2. The obtained results implied that the charged states and hydrophobicity of the water-soluble polycarboxylic fullerene derivatives affect significantly their biological properties.
(© 2018 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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