Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature.

Autor: Peña-Jaimes L; Department of Pathology, Hospital Ramón y Cajal, Madrid, Spain., González-García I; Department of Pathology, Hospital Ramón y Cajal, Madrid, Spain., Reguero-Callejas ME; Department of Pathology, Hospital Ramón y Cajal, Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain., Pinilla-Pagnon I; Department of Pathology, Hospital Ramón y Cajal, Madrid, Spain., Pérez-Mies B; Department of Pathology, Hospital Ramón y Cajal, Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.; Universidad de Alcalá de Henares, Madrid, Spain., Albarrán-Artahona V; Department of Oncology, Hospital Ramón y Cajal, Madrid, Spain., Martínez-Jañez N; Department of Oncology, Hospital Ramón y Cajal, Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain., Rosa-Rosa JM; CIBER-ONC, Insituto de Salud Carlos III, Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain., Palacios J; Department of Pathology, Hospital Ramón y Cajal, Madrid, Spain. jose.palacios@salud.madrid.org.; CIBER-ONC, Insituto de Salud Carlos III, Madrid, Spain. jose.palacios@salud.madrid.org.; Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain. jose.palacios@salud.madrid.org.; Universidad de Alcalá de Henares, Madrid, Spain. jose.palacios@salud.madrid.org.
Jazyk: angličtina
Zdroj: Diagnostic pathology [Diagn Pathol] 2018 Aug 28; Vol. 13 (1), pp. 62. Date of Electronic Publication: 2018 Aug 28.
DOI: 10.1186/s13000-018-0744-6
Abstrakt: Background: Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphological variant of invasive lobular carcinoma characterized by higher nuclear atypia and pleomorphism than the classical type. In the best of our knowledge, a PLC with OGCs has not been previously reported.
Case Presentation: We report the case of a 72-year-old woman presenting with a pleomorphic tumor of the left breast with a dense infiltration by OGCs and T lymphocytes with a 10:1 predominance of CD8+ over CD4+ cells. The diagnosis of a lymphoid or mesenchymal neoplasia was excluded after demonstrating keratin expression by the neoplastic cells. The absence of E-cadherin expression and the morphological features were consistent with the diagnosis PLC with OGCs. In addition, we demonstrated the deleterious mutation C.del866C in CDH1gene, but no mutations in any of the other 33 genes analyzed by next generation sequencing.
Conclusions: Breast carcinoma with stromal osteoclast-like giant cells is a very rare tumor, for that reason, the use of the cytologic features and growth patterns in combination with immunohistochemically studies is mandatory for a correct diagnosis of lobular carcinoma. In addition, further studies are necessary to clarify the influence of OGCs in the prognosis of these patients.
Databáze: MEDLINE
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