Stoss therapy using fortified biscuit for vitamin D-deficient children: a novel treatment.

Autor: Moslemi L; Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandran, Iran., Esmaeili Dooki M; Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandran, Iran. esmaeilidooki@yahoo.com., Moghadamnia AA; Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran., Aghamaleki MA; Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandran, Iran., Pornasrollah M; Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandran, Iran., Ashrafianamiri H; Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandran, Iran., Nooreddini HG; Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandran, Iran., Kazemi S; Cellular and Molecular Biology Research Center, Health Research Center, Babol University of Medical Sciences, Babol, Mazandran, Iran., Pouramir M; Cellular and Molecular Biology Research Center, Health Research Center, Babol University of Medical Sciences, Babol, Mazandran, Iran., Bijani A; Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Mazandran, Iran.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2018 Nov; Vol. 84 (5), pp. 662-667. Date of Electronic Publication: 2018 Aug 06.
DOI: 10.1038/s41390-018-0135-4
Abstrakt: Background: To evaluate the efficacy of stoss therapy using fortified biscuit for vitamin D-deficient children.
Methods: A total of 108 children aged 30-72 months with vitamin D deficiency were studied in a randomized single-blind clinical trial. The deficient children were assigned to three groups, namely, vitamin D-fortified biscuit (BG), capsule vitamin D (CG), and ampoule vitamin D (AG). Capsules and biscuits containing 50,000 IU of cholecalciferol were consumed twice per week for 3 consecutive weeks. Ampoules with 300,000 IU of cholecalciferol were injected intramuscularly in a single dose. Three weeks after treatment, serum 25(OH)D concentrations were measured, and the three groups were compared.
Results: Each method of treatment could increase the mean serum 25(OH)D concentration to optimal level. Serum 25(OH)D concentrations ≥100 ng/mL were observed in six children, including four from AG and two from CG (P = 0.09). The comparison of the mean serum 25(OH)D concentrations after treatment showed between ampoule and capsule (P = 0.3) and capsule and biscuit (P = 0.62) were insignificant; however, the ampoule and biscuit groups differed significantly (P = 0.012).
Conclusion: Stoss therapy using fortified biscuit may be an effective way to improve compliance in children who cannot take capsules without adverse effects and may also be recommended for prevention purposes.
Databáze: MEDLINE
Externí odkaz: