Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991-2010 (Automated Childhood Cancer Information System): a population-based study.

Autor:	Steliarova-Foucher E; Section of Cancer Surveillance, International Agency for Research on Cancer, World Health Organization, Lyon, France. Electronic address: steliarova@iarc.fr., Fidler MM; Section of Cancer Surveillance, International Agency for Research on Cancer, World Health Organization, Lyon, France., Colombet M; Section of Cancer Surveillance, International Agency for Research on Cancer, World Health Organization, Lyon, France., Lacour B; French National Registry of Childhood Solid Tumours, Centre Hospitalier Régional Universitaire, Nancy, France; Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Centre (CRESS), Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Paris, France., Kaatsch P; German Childhood Cancer Registry, University Medical Center, Mainz, Germany., Piñeros M; Section of Cancer Surveillance, International Agency for Research on Cancer, World Health Organization, Lyon, France., Soerjomataram I; Section of Cancer Surveillance, International Agency for Research on Cancer, World Health Organization, Lyon, France., Bray F; Section of Cancer Surveillance, International Agency for Research on Cancer, World Health Organization, Lyon, France., Coebergh JW; Department of Public Health, Erasmus MC, Rotterdam, Netherlands., Peris-Bonet R; Spanish Registry of Childhood Tumours (RETI-SEHOP), Faculty of Medicine, University of Valencia, Valencia, Spain., Stiller CA; National Cancer Registration and Analysis Service, Public Health England, London, UK.
Jazyk:	angličtina
Zdroj:	The Lancet. Oncology [Lancet Oncol] 2018 Sep; Vol. 19 (9), pp. 1159-1169. Date of Electronic Publication: 2018 Aug 08.
DOI:	10.1016/S1470-2045(18)30423-6
Abstrakt:	Background: A deceleration in the increase in cancer incidence in children and adolescents has been reported in several national and regional studies in Europe. Based on a large database representing 1·3 billion person-years over the period 1991-2010, we provide a consolidated report on cancer incidence trends at ages 0-19 years. Methods: We invited all population-based cancer registries operating in European countries to participate in this population-based registry study. We requested a listing of individual records of cancer cases, including sex, age, date of birth, date of cancer diagnosis, tumour sequence number, primary site, morphology, behaviour, and the most valid basis of diagnosis. We also requested population counts in each calendar year by sex and age for the registration area, from official national sources, and specific information about the covered area and registration practices. An eligible registry could become a contributor if it provided quality data for all complete calendar years in the period 1991-2010. Incidence rates and the average annual percentage change with 95% CIs were reported for all cancers and major diagnostic groups, by region and overall, separately for children (age 0-14 years) and adolescents (age 15-19 years). We examined and quantified the stability of the trends with joinpoint analyses. Findings: For the years 1991-2010, 53 registries in 19 countries contributed a total of 180 335 unique cases. We excluded 15 162 (8·4%) of 180 335 cases due to differing practices of registration, and considered the quality indicators for the 165 173 cases included to be satisfactory. The average annual age-standardised incidence was 137·5 (95% CI 136·7-138·3) per million person-years and incidence increased significantly by 0·54% (0·44-0·65) per year in children (age 0-14 years) with no change in trend. In adolescents, the combined European incidence was 176·2 (174·4-178·0) per million person-years based on all 35 138 eligible cases and increased significantly by 0·96% (0·73-1·19) per year, although recent changes in rates among adolescents suggest a deceleration in this increasing trend. We observed temporal variations in trends by age group, geographical region, and diagnostic group. The combined age-standardised incidence of leukaemia based on 48 458 cases in children was 46·9 (46·5-47·3) per million person-years and increased significantly by 0·66% (0·48-0·84) per year. The average overall incidence of leukaemia in adolescents was 23·6 (22·9-24·3) per million person-years, based on 4702 cases, and the average annual change was 0·93% (0·49-1·37). We also observed increasing incidence of lymphoma in adolescents (average annual change 1·04% [0·65-1·44], malignant CNS tumours in children (average annual change 0·49% [0·20-0·77]), and other tumours in both children (average annual change 0·56 [0·40-0·72]) and adolescents (average annual change 1·17 [0·82-1·53]). Interpretation: Improvements in the diagnosis and registration of cancers over time could partly explain the observed increase in incidence, although some changes in underlying putative risk factors cannot be excluded. Cancer incidence trends in this young population require continued monitoring at an international level. Funding: Federal Ministry of Health of the Federal German Government, the European Union's Seventh Framework Programme, and International Agency for Research on Cancer. (This is an Open Access article published under the CC BY-NC-ND 3.0 IGO license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any use of this article, there should be no suggestion that WHO endorses any specific organisation, products, or services. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu