Serum leptin and homeostasis model assessment-IR as novel predictors of early liver fibrosis in chronic hepatitis B virus infection.

Autor:	Mousa N; a Department of Tropical Medicine , Mansoura University , Mansoura , Egypt., Abdel-Razik A; a Department of Tropical Medicine , Mansoura University , Mansoura , Egypt., Sheta T; b Internal Medicine Department , Mansoura University , Mansoura , Egypt., Shabana W; a Department of Tropical Medicine , Mansoura University , Mansoura , Egypt., Zakaria S; a Department of Tropical Medicine , Mansoura University , Mansoura , Egypt., Awad M; b Internal Medicine Department , Mansoura University , Mansoura , Egypt., Abd Elsalam M; b Internal Medicine Department , Mansoura University , Mansoura , Egypt., El-Wakeel N; c Department of Medical Microbiology and Immunology , Mansoura University , Mansoura , Egypt., Elkashef W; d Department of Pathology , Mansoura University , Mansoura , Egypt., Effat N; e Clinical Pathology Department , Mansoura University , Mansoura , Egypt., Elgamal A; f Department of Tropical Medicine , Menoufia University , Mansoura , Egypt., Deiab AG; b Internal Medicine Department , Mansoura University , Mansoura , Egypt., Eldars W; c Department of Medical Microbiology and Immunology , Mansoura University , Mansoura , Egypt.
Jazyk:	angličtina
Zdroj:	British journal of biomedical science [Br J Biomed Sci] 2018 Oct; Vol. 75 (4), pp. 192-196. Date of Electronic Publication: 2018 Sep 07.
DOI:	10.1080/09674845.2018.1505187
Abstrakt:	Background: The relationship between hepatitis B virus (HBV) infection, leptin and insulin resistance remains unclear. We hypothesised links between serum leptin and insulin resistance in non-diabetic patients with chronic viral hepatitis B infection and their relation to liver fibrosis. Methods: We recruited 190 untreated patients with chronic HBV infection and 72 healthy controls. Serum leptin, fasting glucose, insulin, liver function tests (LFTs), C-peptide and Homeostasis model assessment-IR (HOMA-IR) were measured/calculated by ELISA and standard techniques. Results: Serum leptin, C-peptide (both P < 0.001), HOMA-IR (P = 0.021) and several LFTs were increased in patients with chronic HBV-infection. In multivariate regression analysis, both HOMA-IR (P = 0.003) and leptin (P = 0.002) were significant independent predictors of HBV infection. There were significant positive correlations (P < 0.01) between leptin and HOMA-IR (r = 0.81), between serum leptin and METAVIR activity (r = 0.95), and between HOMA-IR and BMI (r = 0.75), fasting glucose (r = 0.005), and fasting insulin (r = 0.81). Several LFTs, glucose and insulin correlated modestly (r = 0.61-0.69, P < 0.05) with leptin. Conclusion: Serum leptin may be related to the rate of fibrosis progression in nondiabetic patients with chronic HBV infection. Follow-up by serial measurement of serum leptin and HOMA-IR in non diabetic HBV-infected patients may be used as a non-invasive marker of early liver fibrosis.
Databáze:	MEDLINE
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