Function of AT1 and AT2 receptors in atrial contractions from spontaneous hypertensive and diabetic-induced streptozotocin rats.

Autor: Musial DC; Departamento de Farmacología, Universidade Federal de São Paulo, São Paulo, Brazil.; Centro de Ciências da Saúde e do Desporto, Universidade Federal do Acre, São Paulo, Brazil., Miranda-Ferreira R; Departamento de Farmacología, Universidade Federal de São Paulo, São Paulo, Brazil., Padin JF; Departamento Ciencias Médicas (Farmacología), Facultad de Medicina, Universidad de Castilla-La Mancha (UCLM), Ciudad Real, España., Arranz-Tagarro JA; Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.; Instituto Teófilo Hernando, Madrid, Spain., Parra-Vitela AJ; THRCE - Tulane Hypertension and Renal Center of Excellence, Department of Physiology, School of Medicine, Tulane University, New Orleans, Louisiana., Jurkiewicz A; Departamento de Farmacología, Universidade Federal de São Paulo, São Paulo, Brazil., Garcia AG; Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.; Instituto Teófilo Hernando, Madrid, Spain., Jurkiewicz NH; Departamento de Farmacología, Universidade Federal de São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2018 Dec; Vol. 45 (12), pp. 1274-1285. Date of Electronic Publication: 2018 Sep 03.
DOI: 10.1111/1440-1681.13019
Abstrakt: Diabetes mellitus and hypertension are diseases that are strongly correlated. A major factor in this correlation is the renin-angiotensin system (RAS), with the peptide angiotensin II being a key component. This study analyzed the impact of Angiotensin Type 1 receptor (AT1R) and Angiotension Type 2 receptor (AT2R) in atrial function. MAIN METHODS: To perform the experiments, Wistar Kyoto rats (WKY), diabetic streptozotocin-induced WKY rats and spontaneously hypertensive rats (SHR) were used, and stimulation of cardiovascular function was done by means of the following drugs: angiotensin II, novokinin and the antagonists losartan and PD123177. We also measured the systolic blood pressure (SBP). RESULTS: An increase in AT1R function was observed in diabetic and hypertensive rats (18% in right atria [RA] and 11% in left atria [LA]). We also observed an increase in calcium release from the endoplasmic reticulum in right atria of diabetic rats (31%) and in right atria of hypertensive rats (35%). On the other hand, a decreased response of AT2R in diabetic and hypertensive rats was observed, this decreased response was greater in hypertensive rats (RA, 10%; LA, 12%). These results have demonstrated a dysfunction of the RAS that may contribute to the common dysfunctions of the cardiovascular system in diabetic and hypertensive rats.
(© 2018 John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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