Papio spp. Colon microbiome and its link to obesity in pregnancy.

Autor: Li X; Department of Biology, University of Copenhagen, Universitetsparken, Denmark., Rensing C; Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.; J. Craig Venter Institute, La Jolla, California., Taylor WL; Molecular Resource Center, University of Tennessee Health Science Center, Memphis, Tennessee., Costelle C; Molecular Resource Center, University of Tennessee Health Science Center, Memphis, Tennessee., Brejnrod AD; Department of Biology, University of Copenhagen, Universitetsparken, Denmark., Ferry RJ Jr; Psychology Department, University of Memphis, Memphis, Tennessee., Higgins PB; Texas Biomedical Research Institute, San Antonio, Texas., Folli F; Endocrinology and Metabolism, Department of Health Science, University of Milano and ASST Santi Paolo e Carlo, Milano, Italy., Kottapalli KR; Center for Biotechnology and Genomics, Texas Tech University, Lubbock, Texas., Hubbard GB; University of Texas Health Sciences Center at San Antonio, San Antonio, Texas., Dick EJ Jr; Texas Biomedical Research Institute, San Antonio, Texas., Yooseph S; J. Craig Venter Institute, La Jolla, California.; Department of Computer Science, University of Central Florida, Orlando, Florida., Nelson KE; J. Craig Venter Institute, La Jolla, California., Schlabritz-Loutsevitch N; Department of Obstetrics and Gynecology, College of Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas.
Jazyk: angličtina
Zdroj: Journal of medical primatology [J Med Primatol] 2018 Dec; Vol. 47 (6), pp. 393-401. Date of Electronic Publication: 2018 Jul 24.
DOI: 10.1111/jmp.12366
Abstrakt: Introduction: Gut microbial communities are critical players in the pathogenesis of obesity. Pregnancy is associated with increased bacterial load and changes in gut bacterial diversity. Sparse data exist regarding composition of gut microbial communities in obesity combined with pregnancy.
Material and Methods: Banked tissues were collected under sterile conditions during necropsy, from three non-obese (nOb) and four obese (Ob) near-term pregnant baboons. Sequences were assigned taxonomy using the Ribosomal Database Project classifier. Microbiome abundance and its difference between distinct groups were assessed by a nonparametric test.
Results: Three families predominated in both the nOb and Ob colonic microbiome: Prevotellaceae (25.98% and 32.71% respectively), Ruminococcaceae (12.96% and 7.48%), and Lachnospiraceae (8.78% and 11.74%). Seven families of the colon microbiome displayed differences between Ob and nOb groups.
Conclusion: Changes in gut microbiome in pregnant obese animals open the venue for dietary manipulation in pregnancy.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje