Selective vulnerability of hippocampal interneurons to graded traumatic brain injury.

Autor: Frankowski JC; Department of Anatomy & Neurobiology, University of California, Irvine, CA 92697, USA., Kim YJ; Department of Anatomy & Neurobiology, University of California, Irvine, CA 92697, USA., Hunt RF; Department of Anatomy & Neurobiology, University of California, Irvine, CA 92697, USA. Electronic address: robert.hunt@uci.edu.
Jazyk: angličtina
Zdroj: Neurobiology of disease [Neurobiol Dis] 2019 Sep; Vol. 129, pp. 208-216. Date of Electronic Publication: 2018 Jul 19.
DOI: 10.1016/j.nbd.2018.07.022
Abstrakt: Traumatic brain injury is a major risk factor for many long-term mental health problems. Although underlying mechanisms likely involve compromised inhibition, little is known about how individual subpopulations of interneurons are affected by neurotrauma. Here we report long-term loss of hippocampal interneurons following controlled cortical impact (CCI) injury in young-adult mice, a model of focal cortical contusion injury in humans. Brain injured mice displayed subfield and cell-type specific decreases in interneurons 30 days after impact depths of 0.5 mm and 1.0 mm, and increasing the depth of impact led to greater cell loss. In general, we found a preferential reduction of interneuron cohorts located in principal cell and polymorph layers, while cell types positioned in the molecular layer appeared well preserved. Our results suggest a dramatic shift of interneuron diversity following contusion injury that may contribute to the pathophysiology of traumatic brain injury.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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