MICA-129 A/G dimorphism, its relation to soluble mica plasma level and spontaneous preterm birth: A case-control study.

Autor: Von Linsingen R; Department of Gynecology and Obstetrics, Infectious diseases in Gynecology and Obstetrics Sector, Clinics Hospital of University of Paraná (UFPR), Post Graduate Program of Gynecology and Obstetrics, Rua General Carneiro, 181, Alto da Glória, CEP80060-900 Curitiba, Paraná, Brazil. Electronic address: renate.linsingen@gmail.com., Gelmini GF; Genetics Department of Federal University of Paraná. LIGH- Immunogenetics and Histocompatibility Laboratory, Avenida Coronel Francisco H. dos Santos, 100. Centro Politécnico - Jardim das Américas, CEP: 80050-540 Curitiba, Paraná, Brazil. Electronic address: georgiagel@msn.com., Bicalho MDG; Genetics Department of Federal University of Paraná. LIGH- Immunogenetics and Histocompatibility Laboratory, Avenida Coronel Francisco H. dos Santos, 100. Centro Politécnico - Jardim das Américas, CEP: 80050-540 Curitiba, Paraná, Brazil. Electronic address: mgbicalho@gmail.com., De Carvalho NS; Department of Gynecology and Obstetrics, Infectious diseases in Gynecology and Obstetrics Sector, Clinics Hospital of University of Paraná (UFPR), Post Graduate Program of Gynecology and Obstetrics, Rua General Carneiro, 181, Alto da Glória, CEP80060-900 Curitiba, Paraná, Brazil. Electronic address: newtonsdc@gmail.com.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2018 Sep; Vol. 129, pp. 9-14. Date of Electronic Publication: 2018 Jul 10.
DOI: 10.1016/j.jri.2018.07.002
Abstrakt: The aim of this case- control study was to investigate the association between preterm birth (PTB), MICA-129 A/G dimorphism and sMICA levels. Fifty pregnant women with singleton pregnancy and previous PTB, or clinic diagnostic of threatened preterm labor in the actual pregnancy, or cervical length less than 25 mm and 50 healthy pregnant women were enrolled. DNA was extracted for genotyping for MICA-129 A/G by real-time PCR and sMICA plasma level was quantified by sandwich ELISA assay. Clinical and socioeconomic characteristics, results of TaqMan® genotyping and ELISA quantification were compared between the groups using qui-square, Fisher´s exact or Mann-Whitney test. A binary logistic regression model was used to predict PTB. The correlation between MICA-129 A/G genotypes and sMICA levels was investigated. There were not statistically significant differences between MICA-129 A/G polymorphism and sMICA plasma level.There was found a correlation between MICA-129 val/val genotype and higher levels of sMICA (ρ: -0.342; p:0.001). The presence of MICA-129  val/val genotype may be influencing sMICA expression.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: