Global Transcriptome Changes of Biofilm-Forming Staphylococcus epidermidis Responding to Total Alkaloids of Sophorea alopecuroides.

Autor:	Guan CP; Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources in Western China, Ningxia University,Yinchuan, Ningxia,China., Luo HX; Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources in Western China, Ningxia University,Yinchuan, Ningxia,China., Fang HE; Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources in Western China, Ningxia University,Yinchuan, Ningxia,China., Zhou XZ; Key Laboratory of the Ministry of Education for the Conservation and Utilization of Special Biological Resources in Western China, Ningxia University,Yinchuan, Ningxia,China.
Jazyk:	angličtina
Zdroj:	Polish journal of microbiology [Pol J Microbiol] 2018 Jun 30; Vol. 67 (2), pp. 223-226.
DOI:	10.21307/pjm-2018-024
Abstrakt:	Transcriptome changes of biofilm-forming Staphylococcus epidermidis response to total alkaloids of Sophorea alopecuroides was observed. Bioinformatic analyses were further used to compare the differential gene expression between control and the treated samples. It was found that 282 genes were differentially expressed, with 92 up-regulated and 190 down-regulated. These involved down-regulation of the sulfur metabolism pathway. It was suggested that inhibitory effects on Staphylococcus epidermidis and its biofilm formation of the total alkaloids of S. alopecuroides was mainly due to the regulation of the sulfur metabolism pathways of S. epidermidis.
Databáze:	MEDLINE
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