Treatment with either leflunomide or adalimumab reduces anaemia in patients with rheumatoid arthritis.

Autor:	Pereira ICP; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil., Sousa NCF; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil., Pereira DMS; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil., Mendes SJF; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil., Muniz TF; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil., Colares VLP; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil., Silva BLR; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil., Monteiro CRAV; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil.; Universidade Federal do Maranhão, Av. dos Portugueses, 1966, Vila Bacanga, 65085-580 São Luís, MA, Brazil., Martins MMRS; Centro de Especialidades Médicas Vinhais, Av. 02, Vinhais, 65070-000 São Luís, MA, Brazil., Fernandes AMR; Curso de Graduação em Ciência da Computação, Universidade do Vale do Itajaí, Campus Kobrasol, Km 207, MundoCar Shopping, Kobrasol, 88102-700 São José, SC, Brazil., Fernandes ES; Programa de Pós-graduação, Universidade Ceuma, Rua Josué Montello, 1, Bairro Renascença II, 65075-120 São Luis, MA, Brazil.
Jazyk:	angličtina
Zdroj:	Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2018 Aug; Vol. 90 (2 suppl 1), pp. 2161-2166. Date of Electronic Publication: 2018 Jun 25.
DOI:	10.1590/0001-3765201820170091
Abstrakt:	Rheumatoid arthritis is a chronic disease of the joints, which causes joint pain and disability. Anaemia is a frequent extra-articular manifestation in rheumatoid arthritis, affecting 30-70% of the patients; presenting a negative impact on patient´s quality of life. Some of the drugs used in rheumatoid arthritis treatment improve anaemia; but little is known on the beneficial effects of the anti-rheumatic leflunomide or the anti-TNFα adalimumab, in this parameter. We investigated the incidence of anaemia in rheumatoid arthritis patients treated or not with leflunomide or adalimumab. We also assessed whether anaemia correlates with disease activity. Anaemia was present in patients who had just been diagnosed with rheumatoid arthritis and had never taken disease modifying agents or biologicals (non-specific therapy group), but not in those taking either leflunomide or adalimumab. The erythrocyte sedimentation rate was increased in patients with non-specific therapy in comparison with those taking either leflunomide or adalimumab. Anaemia correlated with increased erythrocyte sedimentation rate. We suggest that leflunomide and adalimumab may be useful in treating anaemia in patients with rheumatoid arthritis.
Databáze:	MEDLINE
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