Amyotrophic lateral sclerosis: The complement and inflammatory hypothesis.

Autor: Kjældgaard AL; Laboratory of Molecular Medicine, Department of Clinical Immunology, Diagnostic Centre, Section 7631; Department of Neuroanaesthesiology. Electronic address: anne-lene.kjaeldgaard@regionh.dk., Pilely K; Laboratory of Molecular Medicine, Department of Clinical Immunology, Diagnostic Centre, Section 7631., Olsen KS; Department of Neuroanaesthesiology., Pedersen SW; Department of Neurology, Neuroscience Centre, Rigshospitalet, Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Lauritsen AØ; Department of Neuroanaesthesiology., Møller K; Department of Neuroanaesthesiology., Garred P; Laboratory of Molecular Medicine, Department of Clinical Immunology, Diagnostic Centre, Section 7631.
Jazyk: angličtina
Zdroj: Molecular immunology [Mol Immunol] 2018 Oct; Vol. 102, pp. 14-25. Date of Electronic Publication: 2018 Jun 20.
DOI: 10.1016/j.molimm.2018.06.007
Abstrakt: Amyotrophic lateral sclerosis (ALS) is a devastating, neurodegenerative motor neuron disease. The aetiology of ALS remains an enigma which hinders the design of an effective treatment to prevent, postpone, or reverse the pathophysiological changes occurring during the aggressive progression of this disease. During the last decade, basic research within the innate immune system, and in particular the complement system, has revealed new, important roles of the innate immune system during development, homeostasis, and ageing within as well as outside the central nervous system. Several lines of evidence indicate that aberrant activation of the complement system locally in the central nervous system as well as systemically may be involved in the pathophysiology of ALS. This exciting new knowledge could point towards the innate immune system as a potential target of medical intervention in ALS. Recently, the historic perception of ALS as a central neurodegenerative disease has been challenged due to the significant amount of evidence of a dying-back mechanism causing the selective destruction of the motor neurons, indicating that disease onset occurs outside the borders of the blood-brain-barrier. This review addresses the function of the innate immune system during ALS. We emphasize the role of the complement system and specifically suggest the involvement of ficolin-3 from the lectin pathway in the pathophysiology of ALS.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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