Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children.

Autor: Hmeidi H; Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, UK., Motamedi-Fakhr S; PneumaCare Ltd., Ely, Cambridgeshire, UK., Chadwick EK; Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, UK., Gilchrist FJ; Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, UK.; University Hospitals of North Midlands, Stoke-on-Trent, UK., Lenney W; Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, UK.; University Hospitals of North Midlands, Stoke-on-Trent, UK., Iles R; PneumaCare Ltd., Ely, Cambridgeshire, UK.; Addenbrooke's Hospital, Cambridge, UK., Wilson RC; PneumaCare Ltd., Ely, Cambridgeshire, UK., Alexander J; University Hospitals of North Midlands, Stoke-on-Trent, UK.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2018 Jun; Vol. 6 (12), pp. e13752.
DOI: 10.14814/phy2.13752
Abstrakt: Measurement of lung function can be difficult in young children. Structured light plethysmography (SLP) is a novel, noncontact method of measuring tidal breathing that monitors displacement of the thoraco-abdominal wall. SLP was used to compare breathing in children recovering from an acute exacerbation of asthma/wheeze and an age-matched cohort of controls. Children aged 2-12 years with acute asthma/wheeze (n = 39) underwent two 5-min SLP assessments, one before bronchodilator treatment and one after. SLP was performed once in controls (n = 54). Nonparametric comparisons of patients to healthy children and of pre-bronchodilator to post-bronchodilator were made for all children, and also stratified by age group (2-5 vs. 6-12 years old). In the asthma/wheeze group, IE50 SLP (inspiratory to expiratory flow ratio) was higher (median 1.47 vs. 1.31; P = 0.002), thoraco-abdominal asynchrony (TAA) and left-right asynchrony were greater (both P < 0.001), and respiratory rate was faster (P < 0.001) than in controls. All other timing indices were shorter and displayed reduced variability (all P < 0.001). Variability in time to peak inspiratory flow was also reduced (P < 0.001). Younger children showed a greater effect than older children for TAA (interaction P < 0.05). After bronchodilator treatment, the overall cohort showed a reduction in within-subject variability in time to peak expiratory flow only (P < 0.001). Younger children exhibited a reduction in relative contribution of the thorax, TAA, and variability in TAA (interaction P < 0.05). SLP can be successfully performed in young children. The potential of SLP to monitor diseases such as asthma in children is worthy of further investigation. ClinicalTrials.gov identifier: NCT02543333.
(© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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