Depressed female smokers have higher levels of soluble tumor necrosis factor receptor 1.

Autor:	Porcu M; Center of Approach and Treatment for Smokers, University Hospital, Londrina State University, Campus Universitário, Londrina, Paraná, Brazil.; Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., Machado RCBR; Center of Approach and Treatment for Smokers, University Hospital, Londrina State University, Campus Universitário, Londrina, Paraná, Brazil.; Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., Urbano M; Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil.; Department of Statistics, Center of Exact Sciences, Londrina State University, Londrina, Brazil., Verri WA Jr; Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil.; Department of Pathology, Biological Sciences Center, Londrina State University, Brazil., Rossaneis AC; Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil., Vargas HO; Department of Clinical Medicine, Londrina State University (UEL), Health Sciences Centre, Londrina, Paraná, Brazil.; Center of Approach and Treatment for Smokers, University Hospital, Londrina State University, Campus Universitário, Londrina, Paraná, Brazil., Nunes SOV; Department of Clinical Medicine, Londrina State University (UEL), Health Sciences Centre, Londrina, Paraná, Brazil.; Center of Approach and Treatment for Smokers, University Hospital, Londrina State University, Campus Universitário, Londrina, Paraná, Brazil.; Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil.
Jazyk:	angličtina
Zdroj:	Addictive behaviors reports [Addict Behav Rep] 2018 Mar 28; Vol. 7, pp. 90-95. Date of Electronic Publication: 2018 Mar 28 (Print Publication: 2018).
DOI:	10.1016/j.abrep.2018.03.004
Abstrakt:	Aim: To examine clinical and biomarkers in depressed female smokers, in order to better clarify the process that link mood disorders, childhood trauma and smoking in women. Methods: The clinical sample comprised women with unipolar or bipolar depression, divided into subgroups of smokers and never-smoker. The control groups comprised two subgroups non-depressed women, separated into smokers and never-smokers. A structured questionnaire was used to assess socio-demographic and clinical data. The following scales were used: 17-item version Hamilton Depression Rating Scale, Hamilton Anxiety Rating scale (HAM-A), Sheehan disability scale, the Child Trauma Questionnaire. The following biomarkers were investigated: lipid profile, including total cholesterol, high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol, triglycerides the Castelli's Risk indexes I and II; and cytokines, including interleukins (IL)-1β, IL-6, IL-10, IL-12, soluble tumor necrosis factor receptor 1 (sTNF-R1). Results: Depressed female smokers showed a number of significant positive correlations: emotional neglect and sTNF-R1 ( p  = 0.02); waist circumference and sTNF-R1 ( p  = 0.001); body mass index and sTNF-R1 ( p  < 0.01); HAM-A and sTNF-R1 ( p  = 0.03); IL-1β and sTNF-R1 ( p  < 0.01); IL-10 and sTNF-R1 ( p  = 0.001); IL-12 and sTNF-R1 ( p  < 0.01);Castelli index I and sTNF-R1 ( p  < 0.01); Castelli index II and sTNF-R1 ( p  < 0.01); and a significantly negative correlation between HDLc and sTNF-R1( p  = 0.014). Conclusion: This study suggests that depressed female smokers who experienced more childhood trauma and had more anxiety symptoms are associated with the activation of inflammatory processes and alterations in components of lipid profile.
Databáze:	MEDLINE
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