β-lactam antibiotics & vancomycin increase the growth & virulence of Candida spp.

Autor:	Aguiar Cordeiro R; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Jesus Evangelista AJ; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., Serpa R; Departament of of Plant Protection, Federal University of Pelotas, Rio Grande do Sul, Brazil., Colares de Andrade AR; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., Leite Mendes PB; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., Silva Franco JD; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Oliveira JS; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Alencar LP; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., Sales JA; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.; Department of Veterinary Medicine, Post Graduate Program in Veterinary Sciences, College of Veterinary Medicine, State University of Ceará, Fortaleza, Ceará, Brazil., Carneiro Câmara LM; Department of Pathology & Legal Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Souza Collares Maia Castelo-Branco D; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., Nogueira Brilhante RS; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., Costa Sidrim JJ; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil., Gadelha Rocha MF; Department of Pathology & Legal Medicine, Medical Mycology Specialized Center, Federal University of Ceará, Fortaleza, Ceará, Brazil.; Department of Veterinary Medicine, Post Graduate Program in Veterinary Sciences, College of Veterinary Medicine, State University of Ceará, Fortaleza, Ceará, Brazil.
Jazyk:	angličtina
Zdroj:	Future microbiology [Future Microbiol] 2018 Jun 01; Vol. 13, pp. 869-875. Date of Electronic Publication: 2018 Jun 08.
DOI:	10.2217/fmb-2018-0019
Abstrakt:	Aim: To investigate the direct effect of antibiotics on growth and virulence of the major Candida species associated with invasive infections. Materials & Methods: Cefepime, imipenem, meropenem, amoxicillin and vancomycin were tested at twofold the peak plasma concentration (2× PP) and the peak plasma concentration (PP). The effects of antibiotics on Candida albicans, Candida parapsilosis, Candida krusei and Candida tropicalis were investigated by colony counting, flow cytometry, proteolytic activity and virulence in Caenorhabditis elegans. Results: Antibiotics increase growth and proteolytic activity of Candida spp; In addition, amoxicillin potentiates virulence of C. krusei and C. tropicalis against Caenorhabditis elegans. Conclusion: These results suggest that antimicrobial therapy may have a direct effect on the pathophysiology of invasive fungal infections in patients at risk.
Databáze:	MEDLINE
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