Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria.

Autor:	Costa PAC; Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, Minas Gerais, Brazil., Figueiredo MM; Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, Minas Gerais, Brazil.; Laboratório de Imunopatologia, Belo Horizonte, Minas Gerais, Brazil., Diniz SQ; Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, Minas Gerais, Brazil.; Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Peixoto APMM; Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, Minas Gerais, Brazil., Maloy KJ; Sir William Dunn School of Pathology, University of Oxford, United Kingdom., Teixeira-Carvalho A; Grupo Integrado de Pesquisas em Biomarcadores, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil., Tada MS; Centro de Pesquisas em Medicina Tropical de Rondônia, Porto Velho, Brazil., Pereira DB; Centro de Pesquisas em Medicina Tropical de Rondônia, Porto Velho, Brazil., Gazzinelli RT; Laboratório de Imunopatologia, Belo Horizonte, Minas Gerais, Brazil.; Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Antonelli LRV; Laboratório de Biologia e Imunologia de Doenças Infecciosas e Parasitárias, Belo Horizonte, Minas Gerais, Brazil.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2018 Sep 08; Vol. 218 (8), pp. 1314-1323.
DOI:	10.1093/infdis/jiy296
Abstrakt:	The balance between pro- and antiinflammatory mechanisms is essential to limit immune-mediated pathology, and CD4+ forkhead box P3 (Foxp3+) regulatory T cells (Treg) play an important role in this process. The expression of inhibitory receptors regulates cytokine production by Plasmodium vivax-specific T cells. Our goal was to assess the induction of programmed death-1 (PD-1) and cytotoxic T-lymphocyte antigen (CTLA-4) on Treg during malaria and to evaluate their function. We found that P. vivax infection triggered an increase in circulating Treg and their expression of CTLA-4 and PD-1. Functional analysis demonstrated that Treg from malaria patients had impaired suppressive ability and PD-1+Treg displayed lower levels of Foxp3 and Helios, but had higher frequencies of T-box transcription factor+ and interferon-gamma+ cells than PD-1-Treg. Thus malaria infection alters the function of circulating Treg by triggering increased expression of PD-1 on Treg that is associated with decreased regulatory function and increased proinflammatory characteristics.
Databáze:	MEDLINE
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