| Autor: |
Holmes Iv JH; Wake Forest Baptist Medical Center, Winston-Salem, North Carolina., Molnar JA; Wake Forest Baptist Medical Center, Winston-Salem, North Carolina., Carter JE; University Medical Center, New Orleans, Louisiana., Hwang J; University of Alabama-Birmingham, Birmingham, Alabama., Cairns BA; University of North Carolina, Chapel Hill, North Carolina., King BT; U.S. Army Institute for Surgical Research, Fort Sam Houston, Texas., Smith DJ; University of South Florida, Tampa, Florida., Cruse CW; University of South Florida, Tampa, Florida., Foster KN; Maricopa Health System, Phoenix, Arizona., Peck MD; Wake Forest Baptist Medical Center, Winston-Salem, North Carolina., Sood R; University of Indiana, Indianapolis, Indiana., Feldman MJ; Virginia Commonwealth University, Richmond, Virginia Commonwealth University, Richmond, Virginia., Jordan MH; MedStar Washington Hospital Center, Washington, District of Columbia., Mozingo DW; University of Florida, Gainesville, Florida., Greenhalgh DG; University of California Davis, Sacramento, California., Palmieri TL; University of California Davis, Sacramento, California., Griswold JA; Texas Tech University Health Sciences Center, Lubbock, Texas., Dissanaike S; Texas Tech University Health Sciences Center, Lubbock, Texas., Hickerson WL; University of Tennessee, Memphis, Tennessee. |
| Abstrakt: |
Early excision and autografting are standard care for deeper burns. However, donor sites are a source of significant morbidity. To address this, the ReCell® Autologous Cell Harvesting Device (ReCell) was designed for use at the point-of-care to prepare a noncultured, autologous skin cell suspension (ASCS) capable of epidermal regeneration using minimal donor skin. A prospective study was conducted to evaluate the clinical performance of ReCell vs meshed split-thickness skin grafts (STSG, Control) for the treatment of deep partial-thickness burns. Effectiveness measures were assessed to 1 year for both ASCS and Control treatment sites and donor sites, including the incidence of healing, scarring, and pain. At 4 weeks, 98% of the ASCS-treated sites were healed compared with 100% of the Controls. Pain and assessments of scarring at the treatment sites were reported to be similar between groups. Significant differences were observed between ReCell and Control donor sites. The mean ReCell donor area was approximately 40 times smaller than that of the Control (P < .0001), and after 1 week, significantly more ReCell donor sites were healed than Controls (P = .04). Over the first 16 weeks, patients reported significantly less pain at the ReCell donor sites compared with Controls (P ≤ .05 at each time point). Long-term patients reported higher satisfaction with ReCell donor site outcomes compared with the Controls. This study provides evidence that the treatment of deep partial-thickness burns with ASCS results in comparable healing, with significantly reduced donor site size and pain and improved appearance relative to STSG. |
