Dynamics of Expression of Cytokine Genes and Macrophage Content in the Lungs and Kidneys after Subtotal Hepatectomy in Rats.

Autor: El'chaninov AV; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; Peoples' Friendship University of Russia, Moscow, Russia., Fatkhudinov TK; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. fatkhudinov@gmail.com.; Peoples' Friendship University of Russia, Moscow, Russia. fatkhudinov@gmail.com., Arutyunyan IV; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia., Makarov AV; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Usman NY; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia., Mikhailova LP; Research Institute of Human Morphology, Moscow, Russia., Lokhonina AV; V. I. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia., Botchey VM; Peoples' Friendship University of Russia, Moscow, Russia., Glinkina VV; N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Bol'shakova GB; Research Institute of Human Morphology, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 May; Vol. 165 (1), pp. 136-141. Date of Electronic Publication: 2018 May 24.
DOI: 10.1007/s10517-018-4115-9
Abstrakt: The role of the lungs and kidneys in liver regeneration after subtotal hepatectomy was studied on a rat model. It was found that production of hepatocyte growth factor (HGF) in the lungs and kidneys and expression of cytokine genes Il1b, Il6, Il10, and tnfa significantly increased. Analysis of the dynamics of lung macrophage population showed that accumulation of HGF and the increase in the expression of cytokine genes in the lungs were accompanied by simultaneous increase in the number of CD68 + cells, which attested to the leading role of macrophages in activation of HGF synthesis in the lungs. Macrophage content in the kidneys after subtotal hepatectomy did not increase.
Databáze: MEDLINE
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