Replay of Episodic Memories in the Rat.
| Autor: | Panoz-Brown D; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Iyer V; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Carey LM; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Sluka CM; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Rajic G; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Kestenman J; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Gentry M; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Brotheridge S; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Somekh I; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Corbin HE; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Tucker KG; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Almeida B; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Hex SB; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Garcia KD; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA., Hohmann AG; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA; Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405, USA., Crystal JD; Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN 47405, USA. Electronic address: jcrystal@indiana.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Current biology : CB [Curr Biol] 2018 May 21; Vol. 28 (10), pp. 1628-1634.e7. Date of Electronic Publication: 2018 May 10. |
| DOI: | 10.1016/j.cub.2018.04.006 |
| Abstrakt: | Vivid episodic memories in people have been characterized as the replay of multiple unique events in sequential order [1-3]. The hippocampus plays a critical role in episodic memories in both people and rodents [2, 4-6]. Although rats remember multiple unique episodes [7, 8], it is currently unknown if animals "replay" episodic memories. Therefore, we developed an animal model of episodic memory replay. Here, we show that rats can remember a trial-unique stream of multiple episodes and the order in which these events occurred by engaging hippocampal-dependent episodic memory replay. We document that rats rely on episodic memory replay to remember the order of events rather than relying on non-episodic memories. Replay of episodic memories survives a long retention-interval challenge and interference from the memory of other events, which documents that replay is part of long-term episodic memory. The chemogenetic activating drug clozapine N-oxide (CNO), but not vehicle, reversibly impairs episodic memory replay in rats previously injected bilaterally in the hippocampus with a recombinant viral vector containing an inhibitory designer receptor exclusively activated by a designer drug (DREADD; AAV8-hSyn-hM4Di-mCherry). By contrast, two non-episodic memory assessments are unaffected by CNO, showing selectivity of this hippocampal-dependent impairment. Our approach provides an animal model of episodic memory replay, a process by which the rat searches its representations in episodic memory in sequential order to find information. Our findings using rats suggest that the ability to replay a stream of episodic memories is quite old in the evolutionary timescale. (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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