Association between Insulin Resistance and Cardiovascular Risk Factors in Polycystic Ovary Syndrome Patients.
| Autor: | Wanderley MDS; Gynecology and Obstetrics, Faculty of Medicine, Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF, Brazil., Pereira LCR; Gynecology and Obstetrics, Faculty of Medicine, Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF, Brazil., Santos CB; Gynecology and Obstetrics, Faculty of Medicine, Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF, Brazil., Cunha VSD; Gynecology and Obstetrics, Faculty of Medicine, Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF, Brazil., Neves MVJ; Gynecology and Obstetrics, Faculty of Medicine, Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2018 Apr; Vol. 40 (4), pp. 188-195. Date of Electronic Publication: 2018 May 10. |
| DOI: | 10.1055/s-0038-1642634 |
| Abstrakt: | Objective: To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. Methods: Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis. The data were analyzed using the test of proportions, the Chi-square test, and Fisher exact test, when indicated. Results: Out of the 83 patients assessed, aged 28.79 ± 5.85, IR was found in 51.81-66.2% of them using the G/I ratio and the QUICKI, respectively. The test of proportions did not show a significant difference between the methods analyzed. The proportion of IR diagnoses was statistically higher in obese women than in women with normal body mass index (BMI). We observed a statistically significant association between all the methods for diagnosing IR and BMI, waist circumference (WC) and lipid accumulation product (LAP). With regards to arterial hypertension (AH), we observed a significant association according to three methods, with the exception of the ratio G/I. Conclusion: Insulin resistance prevalence varied according to the diagnostic method employed, with no statistical difference between them. The proportion of IR diagnoses was statistically higher in obese women than in women with normal BMI. We observed a significant association between IR and WC, BMI, LAP, as well as dyslipidemia and AH in a high proportion of patients. Competing Interests: The authors have no conflict of interest to disclaim. (Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil.) |
| Databáze: | MEDLINE |
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