[The Clinical Significance of Tumor-associated Antigens in Dermatomyositis Patients with Interstitial Lung Disease].

Autor:	Yang Y; Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu 610041,China., Hao JC; Klinikum Grosshadern,Ludwig-Maximillians University of Munich,Munich 81377,Germany., Chen Y; West China School of Stomatology,Sichuan University,Chengdu 610041,China., Liu Y; Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu 610041,China., Xie QB; Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu 610041,China., Yin G; Department of Ineernational Medical Center/General Practice,West China Hospital,Sichuan University,Chengdu 610041,China.
Jazyk:	čínština
Zdroj:	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2018 Mar; Vol. 49 (2), pp. 195-199.
Abstrakt:	Objective: To investigate the relationship between tumor related markers and the presence of interstitial lung disease (ILD) in dermatomyositis (DM) patients as well as potential serum markers for accompanied ILD. Methods: Fifty-nine DM patients were included,including 30 patents with ILD. Serum level of anti-transcription intermediary factor1-γ (TIF1-γ) and tumor-associated antigens (TAAs) were detected to analyze the correlation of these markers with ILD. Meanwhile,the diagnostic value of these markers was evaluated by receive operating characteristic (ROC) curve analysis. Results: We found that there were 5 patients bearing malignancies,independent from the presence of ILD ( P =0.024). Serum anti-TIF1-γ was positive in 4/5 DM patients with tumor,of which sensitivity and specificity were 36.36% and 97.92%,respectively. In contrast,only one case was found positive anti-TIF1-γ in 30 DM with ILD ( P =0.002).Carbohydrate antigen (CA)125,CA153,and cytokeratin-19 fragment (CYFRA21-1) were elevated in DM patients with ILD in compared to those without ILD. The area under curve ( AUC ) of CYFRA21-1 for the prediction of ILD was 0.745 ( P =0.002). The optimal cut-off value was 3.58 ng/mL with a sensitivity of 60.71% and a specificity of 84.00%. The AUC in combination of CA125 and CYFRA21-1 could reach 0.801 ( P <0.002) with a sensitivity of 64.29% and a specificity of 82.61%. Conclusion: Presence of malignance and positive anti-TIF1γ could be the protective factors for ILD in DM. Elevated serum levels of CA125,CA153,CYFRA21-1 could indicate the accompanying ILD. (Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).)
Databáze:	MEDLINE
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