Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.

Autor: Neukam PT; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany., Kroemer NB; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Deza Araujo YI; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany., Hellrung L; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.; Department of Economics, University of Zürich, Zürich, Switzerland., Pooseh S; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Schwarzenbolz U; Institute of Food Chemistry, Technische Universität Dresden, Dresden, Germany., Henle T; Institute of Food Chemistry, Technische Universität Dresden, Dresden, Germany., Smolka MN; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany. michael.smolka@tu-dresden.de.
Jazyk: angličtina
Zdroj: Psychopharmacology [Psychopharmacology (Berl)] 2018 Jul; Vol. 235 (7), pp. 2151-2165. Date of Electronic Publication: 2018 May 05.
DOI: 10.1007/s00213-018-4913-9
Abstrakt: Rationale: Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making.
Objectives: To test whether high 5-HT levels decrease loss aversion, risk-seeking for gains, and risk-seeking for losses.
Methods: In a first session, 611 participants were genotyped for 5-HTTLPR and performed a mixed gambles (MGA) task and two probability discounting tasks for gains and losses, respectively (PDG/PDL). Afterwards, a subsample of 105 participants (44 with S/S, 6 with S/L, 55 with L/L genotype) completed the pharmacological study using a crossover design with tryptophan depletion (ATD), loading (ATL), and balanced (BAL) conditions. The same decision constructs were assessed.
Results: We found increased risk-seeking for losses in S/S compared to L/L individuals at the first visit (p = 0.002). Neither tryptophan depletion nor loading affected decision-making, nor did we observe an interaction between intervention and 5-HTTLPR genotype.
Conclusion: Our data do not support the idea that transient changes of tonic 5-HT affect value-based decision-making. We provide evidence for an association of 5-HTTLPR with risk-seeking for losses, independent of acute 5-HT levels. This indicates that the association of 5-HTTLPR and risk-seeking for losses is mediated via other mechanisms, possibly by differences in the structural development of neural circuits of the 5-HT system during early life phases.
Databáze: MEDLINE
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