| Autor: |
Eyeington CT, Ancona P, Cioccari L, Luethi N, Glassford NJ; Research Fellow, Department of Anaesthesia, Austin Hospital; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventative Medicine, Monash University; Melbourne, Victoria., Eastwood GM, Proimos HK, Franceschi F, Chan MJ, Jones D; Consultant Intensivist, Associate Professor of Intensive Care, Department of Intensive Care, Austin Hospital; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventative Medicine, Monash University; Melbourne, Victoria., Bellomo R; Consultant Intensivist, Professor of Intensive Care, Director of Intensive Care Research, Department of Intensive Care, Austin Hospital; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventative Medicine, Monash University; Department of Medicine, Melbourne University; Melbourne, Victoria. |
| Abstrakt: |
The primary objective was to non-invasively measure the cardiac index (CI) and associated haemodynamic parameters of healthy volunteers and their changes with age. This was a single centre, prospective, observational study of healthy volunteers aged between 20 and 59 years, using the ClearSight™ (Edwards Life Sciences, Irvine, CA, USA) device. We recorded 514 observations in 97 participants. The mean CI was 3.5 l/min/m 2 (95% confidence interval [95% CI] 3.4 to 3.7 l/min/m 2 ). The mean stroke volume index (SVI) was 47 ml/m 2 (95% CI 45 to 49 ml/m 2 ) and the mean systemic vascular resistance index was 2,242 dyne.s/cm 5 /m 2 (95% CI 2,124 to 2,365 dyne.s/cm 5 /m 2 ). There was an inverse linear relationship between increasing age and CI ( P <0.0001), which decreased by 0.044 l/min/m 2 (95% CI -0.032 to -0.056 l/min/m 2 ) per year. This change was mostly due to a decrease in SVI of 0.45 ml/m 2 (95% CI 0.32 to 0.57 ml/m 2 ) per year ( P <0.0001). The mean CI of young healthy humans is approximately 3.5 l/min/m 2 and declines by approximately 40 ml/min/m 2 per year, mostly due to a decline in stroke volume (SV). These findings have significant implications regarding the clinical interpretation of haemodynamic parameters and the application of these results to individual patients. |
