Prospective multinational serosurveillance study of Bordetella pertussis infection among 10- to 18-year-old Asian children and adolescents.

Autor:	Son S; Samsung Medical Center, Sungkyunkwan University, Department of Pediatrics, Seoul, South Korea., Thamlikitkul V; Faculty of Medicine Siriraj Hospital, Mahidol University, Department of Medicine, Bangkok, Thailand., Chokephaibulkit K; Faculty of Medicine Siriraj Hospital, Mahidol University, Department of Medicine, Bangkok, Thailand., Perera J; University of Colombo, Department of Microbiology, Colombo, Sri Lanka., Jayatilleke K; Sri Jayewardenepura General Hospital, Department of Microbiology, Nugegoda, Sri Lanka., Hsueh PR; National Taiwan University Hospital, Departments of Laboratory Medicine and Internal Medicine, Taipei, Taiwan., Lu CY; National Taiwan University Hospital, Department of Pediatrics, Taipei, Taiwan., Balaji V; Christian Medical College & Hospital, Department of Clinical Microbiology, Vellore, India., Moriuchi H; Graduate School of Biomedical Sciences, Nagasaki University, Department of Molecular Microbiology and Immunology, Nagasaki, Japan., Nakashima Y; Graduate School of Biomedical Sciences, Nagasaki University, Department of Molecular Microbiology and Immunology, Nagasaki, Japan., Lu M; Shanghai Children's Hospital, Department of Pulmonary Medicine, Shanghai, China., Yang Y; Beijing Children's Hospital, Capital Medical University, Department of Microbiology and Immunology, Beijing, China., Yao K; Beijing Children's Hospital, Capital Medical University, Department of Microbiology and Immunology, Beijing, China., Kim SH; Asia Pacific Foundation for Infectious Diseases (APFID), Division of Infectious Disease, Seoul, South Korea., Song JH; Asia Pacific Foundation for Infectious Diseases (APFID), Division of Infectious Disease, Seoul, South Korea., Kim S; Samsung Medical Center, Statistics and Data Center, Seoul, South Korea., Kim MJ; Samsung Medical Center, Statistics and Data Center, Seoul, South Korea., Heininger U; University of Basel Children's Hospital, Pediatric Infectious Diseases and Vaccinology, Basel, Switzerland., Chiu CH; Chang Gung Children's Hospital, Chang Gung University, Department of Pediatrics, Taoyuan, Taiwan. Electronic address: chchiu@cgmh.org.tw., Kim YJ; Samsung Medical Center, Sungkyunkwan University, Department of Pediatrics, Seoul, South Korea. Electronic address: yaejeankim@skku.edu.
Jazyk:	angličtina
Zdroj:	Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2019 Feb; Vol. 25 (2), pp. 250.e1-250.e7. Date of Electronic Publication: 2018 Apr 22.
DOI:	10.1016/j.cmi.2018.04.013
Abstrakt:	Objectives: Bordetella pertussis continues to cause outbreaks worldwide. To assess the role of children and adolescent in transmission of pertussis in Asia, we performed a multinational serosurveillance study. Methods: From July 2013 to June 2016, individuals aged 10 to 18 years who had not received any pertussis-containing vaccine within the prior year were recruited in 10 centres in Asia. Serum anti-pertussis toxin (PT) IgG was measured by ELISA. Demographic data and medical histories were obtained. In the absence of pertussis immunization, anti-PT IgG ≥62.5 IU/mL was interpreted as B. pertussis infection within 12 months prior, among them levels ≥125 IU/mL were further identified as infection within 6 months. Results: A total of 1802 individuals were enrolled. Anti-PT IgG geometric mean concentration was 4.5, and 87 (4.8%) individuals had levels ≥62.5 IU/mL; among them, 73 (83.9%) had received three or more doses of pertussis vaccine before age 6 years. Of 30 participants with persistent cough during the past 6 months, one (3.3%) had level ≥125 IU/mL. There was no significant difference in proportions with anti-PT IgG ≥62.5 IU/mL among age groups (13-15 vs. 10-12 years, 16-18 vs. 10-12 years), between types of diphtheria, pertussis and tetanus (DTP; whole cell vs. acellular), number of doses before age 6 years within the DTP whole-cell pertussis vaccine (five vs. four doses) or acellular pertussis vaccine (five vs. four doses) and history of persistent cough during the past 6 months (yes vs. no). Conclusions: There is significant circulation of B. pertussis amongst Asian children and adolescents, with one in 20 having serologic evidence of recent infection regardless of vaccination background. (Copyright © 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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