Influenza-Associated Parotitis During the 2014-2015 Influenza Season in the United States.

Autor:	Rolfes MA; Epidemic Intelligence Service, Atlanta, Georgia.; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Millman AJ; Epidemic Intelligence Service, Atlanta, Georgia.; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Talley P; Epidemic Intelligence Service, Atlanta, Georgia.; Minnesota Department of Health, St. Paul, Madison., Elbadawi LI; Epidemic Intelligence Service, Atlanta, Georgia.; Bureau of Communicable Disease, Wisconsin Division of Public Health, Madison., Kramer NA; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Barnes JR; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Blanton L; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Davis JP; Bureau of Communicable Disease, Wisconsin Division of Public Health, Madison., Cole S; Michigan Department of Health and Human Services, Lansing., Dreisig JJ; New Hampshire Division of Public Health Services, Concord., Garten R; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Haupt T; Bureau of Communicable Disease, Wisconsin Division of Public Health, Madison., Jackson MA; Children's Mercy Hospital, Kansas City, Missouri., Kocharian A; Bureau of Communicable Disease, Wisconsin Division of Public Health, Madison., Leifer D; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Lynfield R; Minnesota Department of Health, St. Paul, Madison., Martin K; Minnesota Department of Health, St. Paul, Madison., McHugh L; Communicable Disease Service, New Jersey Department of Health, Trenton., Robinson S; Maine Center for Disease Control and Prevention, Maine Department of Health and Human Services, Augusta., Turabelidze G; Missouri Department of Health and Senior Services, St. Louis., Webber LA; Maine Center for Disease Control and Prevention, Maine Department of Health and Human Services, Augusta., Pearce Weinberg M; Epidemic Intelligence Service, Atlanta, Georgia.; Michigan Department of Health and Human Services, Lansing., Wentworth DE; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Finelli L; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia., Jhung MA; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2018 Aug 01; Vol. 67 (4), pp. 485-492.
DOI:	10.1093/cid/ciy136
Abstrakt:	Background: During the 2014-2015 influenza season in the United States, 256 cases of influenza-associated parotitis were reported from 27 states. We conducted a case-control study and laboratory investigation to further describe this rare clinical manifestation of influenza. Methods: During February 2015-April 2015, we interviewed 50 cases (with parotitis) and 124 ill controls (without parotitis) with laboratory-confirmed influenza; participants resided in 11 states and were matched by age, state, hospital admission status, and specimen collection date. Influenza viruses were characterized using real-time polymerase chain reaction and next-generation sequencing. We compared cases and controls using conditional logistic regression. Specimens from additional reported cases were also analyzed. Results: Cases, 73% of whom were aged <20 years, experienced painful (86%), unilateral (68%) parotitis a median of 4 (range, 0-16) days after onset of systemic or respiratory symptoms. Cases were more likely than controls to be male (76% vs 51%; P = .005). We detected influenza A(H3N2) viruses, genetic group 3C.2a, in 100% (32/32) of case and 92% (105/108) of control specimens sequenced (P = .22). Influenza B and A(H3N2) 3C.3 and 3C.3b genetic group virus infections were detected in specimens from additional cases. Conclusions: Influenza-associated parotitis, as reported here and in prior sporadic case reports, seems to occur primarily with influenza A(H3N2) virus infection. Because of the different clinical and infection control considerations for mumps and influenza virus infections, we recommend clinicians consider influenza in the differential diagnoses among patients with acute parotitis during the influenza season.
Databáze:	MEDLINE
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