Screen-detected multiple primary lung cancers in the ITALUNG trial.

Autor:	Mascalchi M; 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Comin CE; Division of Pathological Anatomy, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy., Bertelli E; 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Sali L; 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Maddau C; Institute for Cancer Research and Prevention (ISPO), Florence, Italy., Zuccherelli S; 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Picozzi G; Institute for Cancer Research and Prevention (ISPO), Florence, Italy., Carrozzi L; Cardiopulmonary Department, Pisa University Hospital, Pisa, Italy., Grazzini M; Pulmonology Department, Hospital of Pistoia, Pistoia, Italy., Fontanini G; Pathology Department, University Hospital of Pisa, Pisa, Italy., Voltolini L; Division of Thoracic Surgery, Careggi University Hospital, Florence, Italy., Vella A; Service of Nuclear Medicine, Le Scotte Hospital, Siena, Italy., Castiglione F; Division of Pathological Anatomy, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy., Carozzi F; Institute for Cancer Research and Prevention (ISPO), Florence, Italy., Paci E; Institute for Cancer Research and Prevention (ISPO), Florence, Italy., Zompatori M; Radiology Department, Multimedica Group, IRCCS, Sesto San Giovanni, Italy., Lopes Pegna A; Pulmonology, Cardio-Thoracic-Vascular Department, Careggi Hospital, Florence, Italy., Falaschi F; 2nd Radiology Unit, University Hospital of Pisa, Pisa, Italy.
Jazyk:	angličtina
Zdroj:	Journal of thoracic disease [J Thorac Dis] 2018 Feb; Vol. 10 (2), pp. 1058-1066.
DOI:	10.21037/jtd.2018.01.95
Abstrakt:	Occurrence of multiple primary lung cancers (MPLC) in individuals undergoing low-dose computed tomography (LDCT) screening has not been thoroughly addressed. We investigated MPLC in subjects recruited in the ITALUNG randomized clinical trial. Cases of cytologically/histologically proven MPLC detected at screening LDCT or follow-up CT were selected and pathologically re-evaluated according to the WHO 2015 classification. Overall 16 MPLC were diagnosed at screening LDCT (n=14, all present at baseline) or follow-up CT (n=2) in six subjects (4 in one subject, 3 in two and 2 in three subjects), representing 0.43% of the 1,406 screenees and 15.8% of the 38 subjects with at least one screen-detected primary lung cancer. MPLC included 9 adenocarcinomas in three subjects and a combination of 7 different tumour histotypes in three subjects. MPLC, mostly adenocarcinomas, are not uncommon in smokers and ex-smokers with at least one LDCT screen detected primary lung cancer. Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
Databáze:	MEDLINE
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